The effects of 'Adequacy of Anesthesia' monitorization in general anesthesia on hemodynamics, recovery, and the cost of anesthetic drugs

Objective: Adequacy of anaesthesia provides information about electrical activity of the brain with entropy, and analgesic response of the body with surgical pleth index (SPI). In this study, we aimed to evaluate the effects of anesthetic management performed using adequacy of anaesthesia monitorization on intraoperative hemodynamics, postoperative recovery and the cost of anesthetic drugs. Design: Prospective, randomized and controlled study Setting: Department of Anesthesiology and Reanimation, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Subjects: A total of 120 patients scheduled for thyroidectomy operation under general anesthesia were included in the study. Intervention: Patients divided into two equal groups as Group Adequacy of Anesthesia (Group AoA, n=60) and Group Control (Group C, n=60). For the induction, Group C was maintained with 1-2 mg/kg propofol and 1 mu g/kg remifentanil injection, while based on the entropy and SPI values during the induction, Group AoA was injected with propofol and remifentanil so as to provide state entropy and SPI values of 50 +/- 10. Main outcome measures: Hemodynamic data, times and recovery data were recorded and statistically analyzed. Results: Extubation and recovery times were significantly shorter in Group AoA (P=0.29, P<0,01, P << 0.01; respectively). The cost of anesthesia calculated based on the amount of drugs used was significantly lower in group AoA (P<0.01). Conclusion: In this study where we compared the use of adequacy of anesthesia with conventional anesthetic depth monitorization methods, we found that the use of adequacy of anesthesia provided positive contributions to the cost of anesthetic drugs and post-anesthetic recovery.