Calixarene-based highly efficient primary amine-thiourea organocatalysts for asymmetric Michael addition of aldehydes to nitrostyrenes

Durmaz, MustafaSirit, Abdulkadir2024-02-232024-02-2320131061-02781029-0478https://doi.org/10.1080/10610278.2013.773331https://hdl.handle.net/20.500.12452/13171The synthesis of calix[4]arene-based chiral bifunctional primary aminethiourea catalysts has been described from p-tert-butylcalix[4]arene for the first time. The calix[4]arene-based catalysts were successfully applied to promote Michael addition of aldehydes with nitroalkenes affording preferentially the (R)- or (S)-adducts in high yields (up to 95%) and excellent enantioselectivities (up to 99% ees).eninfo:eu-repo/semantics/closedAccessCalixarenesAsymmetric CatalysisMichael AdditionNitroolefinsOrganocatalysisCalixarene-based highly efficient primary amine-thiourea organocatalysts for asymmetric Michael addition of aldehydes to nitrostyrenesArticle2552923012-s2.0-84876490378Q3WOS:000317721900006Q210.1080/10610278.2013.773331