Baser, AminesenaBasar, BeyzaDogan, Hanim BeyzaSener, GulnurOzsamur, Nezahat GokceCelik, Fatma SecerAltves, Safaa2024-02-232024-02-2320231359-73451364-548Xhttps://doi.org/10.1039/d3cc03453dhttps://hdl.handle.net/20.500.12452/12802A cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1 alpha, VIM, CDH1) related to metastasis is modulated. The stabiliser reprograms hypoxia-adaptive metabolism and an 1.82-fold increase in O2 consumption, enabling back-to-normal switching of energy metabolism, is observed. Stabilisers with a strong G-quadruplex affinity (0.38 mu M Kd) significantly contribute to small molecule anti-cancer approaches. A BODIPY-based G-quadruplex-selective stabiliser is shown to silence regulator genes, reduce cell migration and invasion, and switch off the hypoxia-adaptive metabolism.eninfo:eu-repo/semantics/closedAccess[Keyword Not Available]Article377794982-s2.0-85173710783Q1WOS:00107673400000110.1039/d3cc03453d