Genc, Hayriye NevinOzgun, UmmuSirit, Abdulkadir2024-02-232024-02-2320190899-00421520-636Xhttps://doi.org/10.1002/chir.23055https://hdl.handle.net/20.500.12452/10547A novel type of oxacalix[2]arene[2]triazine-based organocatalysts for asymmetric Michael reactions are reported for the first time. Chiral subunits were attached to the heteroatom-bridged calixaromatic platform by a reaction of (R)- and (S)-1-aminotetraline with tetraoxacalix[2]arene[2]triazine in both enantiomeric forms. To evaluate the catalytic efficiency of the novel organocatalysts, isobutyraldehyde reacted with various substituted and unsubstituted aromatic trans-beta-nitrostyrenes in tetrahydrofuran (THF), leading to Michael adducts in excellent yields and enantioselectivites (up to 97% yield and 99% ee).eninfo:eu-repo/semantics/closedAccessAsymmetric SynthesisMichael AdditionOrganocatalysisStereoselectivityTetraoxacalix[2]Arene[2]TriazineArticle314293300307027752-s2.0-85060955861Q3WOS:000461867500003Q310.1002/chir.23055