Cuce, GokhanEsen, Haci HasanKoc, TugbaCanbaz, Halime TubaLimandal, CisemKalkan, SerpilGurbilek, Mehmet2024-02-232024-02-2320161129-8723https://hdl.handle.net/20.500.12452/17832Purpose: Cyclophosphamide (CP) is a widely used anti chemotherapeutic drug, which causes nephrotoxicity due to its toxic metabolites. This study was carried out to assess the effects of vitamin E on cyclophosphamide induced renal toxicity in rats. Model: Twenty-eight Wistar albino rats were assigned to four groups, which were given 20 mg/kg CP, 20 mg/kg CP + 100 mg/kg vitamin E, 100 mg/kg vitamin E, or 20 mg/kg isotonic sodium chloride solution intraperitoneally each day for 7 days. Effects were assessed by histology of the kidney, TUNEL assay and measurement of serum uric acid and creatinine. Results: Cyclophosphamide significantly increased glomerular inflammation, edema, congestion and tubular degeneration, TUNEL positive cells, while addition of vitamin E significantly decreased glomerular inflammation, edema and TUNEL positive cells. Cyclophosphamide did not affect urea and creatinine levels, which may due to the absence of renal necrosis. Conclusion: Vitamin E application appears to partially ameliorate Cyclophosphamide induced renal toxicity.eninfo:eu-repo/semantics/closedAccessKidneyCyclophosphamideVitamin ETunelArticle1821401452-s2.0-85016263012Q4WOS:000380132900007Q4