Tuzcu, GokselUslu, Ali UgurTuzcu, AycaBaykara, Rabia AydoganOmma, AhmetKucuk, Adem2024-02-232024-02-2320191300-01441303-6165https://doi.org/10.3906/sag-1806-60https://hdl.handle.net/20.500.12452/16081Background/aim: Human endothelial cell-specific molecule-1 (endocan) is a marker of vascular endothelial dysfunction that may be used in the evaluation of inflammatory-associated atherosclerotic lesions. Endocan may be a marker for the evaluation of atherosclerosis and disease activity in rheumatoid arthritis (RA) patients. Materials and methods: We included 39 RA patients assessed according to the American College of Rheumatology/European League Against Rheumatology 2010 diagnostic criteria and recruited 30 age- and sex-matching healthy subjects for the control group. Results: Endocan values were 14.11 +/- 3.27 for the RA patients and 12.10 +/- 2.92 for the controls. The endocan values of the patients were significantly higher than those of the control group (P = 0.009). In the correlation analysis, endocan showed a significantly positive correlation with disease activity score-28 (r = 0.386, P = 0.029) and carotid intima-media thickness (cIMT) (r = 0.419, P = 0.008). Linear regression analysis revealed that there was an independent relationship between endocan and cIMT (P = 0.029). Conclusion: Endocan can be a marker for early atherosclerosis and disease activity in RA patients.eninfo:eu-repo/semantics/openAccessHuman Endothelial Cell-Specific Molecule-1Rheumatoid ArthritisAtherosclerosisCarotid Intima-Media ThicknessMarkerArticle49615991605316555332-s2.0-85076874589Q3WOS:000504051300001Q410.3906/sag-1806-60