Apiliogullari, BurhanKesli, RecepEsme, HidirYuceaktas, AliYoldas, Banu2024-02-232024-02-2320141301-5680https://doi.org/10.5606/tgkdc.dergisi.2014.9362https://hdl.handle.net/20.500.12452/17052Background: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R). Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated. Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S. Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury.eninfo:eu-repo/semantics/closedAccessCarnosolIschemia ReperfusionLungRenal InjuryArticle2248168202-s2.0-84908567797Q3WOS:000344308800017Q410.5606/tgkdc.dergisi.2014.9362