Kocabas, ErdalSariguney, Ahmet BurakErci, FatihCakir-Koc, RabiaKocabas, Hilal OzenTorlak, EmrahCoskun, Ahmet2024-02-232024-02-2320212069-5837https://doi.org/10.33263/BRIAC114.1217812185https://hdl.handle.net/20.500.12452/15761In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.eninfo:eu-repo/semantics/openAccessThiazolePyrrolidineAntibacterial ActivityCytotoxicityArticle11412178121852-s2.0-85100042653Q3WOS:00060632530007610.33263/BRIAC114.1217812185