Sonmez, Mehmet GirayGoger, Yunus EmreEcer, GokhanAtici, AhmetOzkent, Mehmet SerkanOzturk, Ahmet2024-02-232024-02-2320180937-34621433-3023https://doi.org/10.1007/s00192-017-3492-3https://hdl.handle.net/20.500.12452/10841In this study, we planned to explore the effects of sodium bicarbonate orally (NaHCO3) treatment on female patients with lower urinary tract symptoms (LUTS) who have acidic urine pH values (< 6). NaHCO3 was given orally to 33 female patients for 4 weeks at a dose of 2 x 4 g/day. Laboratory values, bladder diary, the Patient Perception of Bladder Condition Score (PPBC), Patient Perception of Intensity of Urgency Scale (PPIUS), Overactive Bladder-Validated 8-question Awareness tool (OAB-V8), Pelvic Pain and Urgency & Frequency Patient Symptom Scale tests (PUFSS), and the King's Health Questionnaire (KHQ) scores before and after treatment were compared. A significant increase was detected in urine pH values measured after treatment (5.31 +/- 0.52 to 7.2 +/- 0.66, p < 0.001), but not in blood pH values (7.369 +/- 0.33 to 7.384 +/- 0.28, p = 0.14). After treatment, a significant decrease was detected in daily frequency, nocturia, urgency, and urge incontinence prevalence (p < 0.001,p = 0.003, p < 0.001, p = 0.002, respectively) and PPBC, PPIUS, PUFSS, and OAB-V8 symptom scores (p = 0.004, p = 0.002, p < 0.001, p < 0.001, respectively). A significant decrease was detected in all KHQ subunit scores. Urine alkalinization with NaHCO3 orally in female patients with LUTS and acidic urine pH has a significant level of positive effects on symptoms and symptom scores. Our results show that this new treatment modality-which is inexpensive, easy to use, and has a low side-effect profile is effective in this chronic patient group.eninfo:eu-repo/semantics/closedAccessUrine AlkalinizationSodium Bicarbonate OrallyLower Urinary Tract SymptomsUrine PhArticle29710291033289753652-s2.0-85030328664Q1WOS:000435584200015Q210.1007/s00192-017-3492-3