Saritas, Tuba BerraCankaya, BarisYosunkaya, Alper2024-02-232024-02-2320142667-6370https://doi.org/10.5152/TJAR.2014.46704https://hdl.handle.net/20.500.12452/16763Neuroleptic malignant syndrome (NMS), caused by antipsychotic therapy, shows itself with mental status alteration, high fever, autonomic dysfunction, and muscle rigidity. It is a rare idiosyncratic reaction with mortality risk. The etiology is still unknown. NMS- related mortality and morbidity can be decreased by cessation of the used drug and aggressive treatment. Olanzapine is a thienobenzodiazepine, a member of atypical antipsychotic drugs; its structure and effects on neurotransmitters resemble clozapine. Here we report a case of bipolar disorder receiving olanzapine therapy for 10 years, who developed NMS without rigidity. We emphasized the importance of early hydration and hemodiafiltration therapy.trinfo:eu-repo/semantics/openAccessNeuroleptic Malignant SyndromeOlanzapineRigidityHemodiafiltrationArticle425288291273664392-s2.0-84907047911WOS:00021863600001210.5152/TJAR.2014.46704