Yildirim, Mehmet AykutKocabas, RahimKilinc, IbrahimSimsek, GurcanSenturk, MustafaCakir, MuratBelviranli, Metin2024-02-232024-02-2320221306-696X1307-7945https://doi.org/10.14744/tjtes.2020.44025https://hdl.handle.net/20.500.12452/15311BACKGROUND: Acute mesenteric ischemia (AMI) is a rarely observed acute abdominal disease that may be mortal and is difficult to diagnose early. The aim of our study is to assess the role of Thiol-Disulphide Haemostasis (TDH), a new method for AMI which still has no specific biochemical markers for early diagnosis, and to assess it together with Ischemia-Modified Albumin (IMA) which METHODS: The study included 32 Wistar albino rats in four groups. The 1st group (n=8) was the control group, 2nd group (n=8) was the sham group, 3rd group (n=8) had 3 h of arterial mesentery ischemia and the 4th group (n=8) had 6 h of arterial mesentery ischemia. RESULTS: In the 3rd and 6th h, serum total thiol and native thiol values significantly reduced (p<0.001), while serum disulfide, IMA, and lactate values clearly increased (p<0.001). Serum thiol values were observed to reduce from the 1st h. CONCLUSION: TDH changes in the early period of AMI. The TDH parameters can be used with IMA as diagnostic parameters for patients with suspected AMI in the early period.eninfo:eu-repo/semantics/openAccessAcute Mesentery IschemiaDisulfideHemostasisThiolArticle284403410354855062-s2.0-85128448531Q2WOS:000781192000001Q410.14744/tjtes.2020.44025