Savdan, MervanÇakır, MuratVatansev, HüsamettinKüçükkartallar, TevfikTekin, AhmetTavlı, Şakir2020-01-182020-01-182017Savdan, M., Çakır, M., Küçükkartallar, T., Tekin, A., Tavlı, Ş., Vatansev, H. (2017). Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery, 33, 2, 62-68.2564-68502564-7032https://dx.doi.org/10.5152/turkjsurg.2017.3337https://app.trdizin.gov.tr/makale/TWpJM05UazVPUT09/preventing-oxygen-free-radical-damage-by-proanthocyanidin-in-obstructive-jaundicehttps://hdl.handle.net/20.500.12452/2739Objective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen freeradicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), whichis a potent exogenous free-radical scavenger and antioxidant.Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of MedicineResearch and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino ratswere used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group(sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in thesecond group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastriclavage for 10 days in the third group.Results: Biochemical values revealed a statistically significant difference between Group I and the others. There wasno difference between Group II and III regarding biochemical values. There was a statistically significant difference,however, between Group II and III with regards to nitric oxide levels. There was a statistically significant differencebetween Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage.Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage causedby oxygen free-radicals.eninfo:eu-repo/semantics/openAccessAntioxidantJaundiceProanthocyanidinArticle3326268WOS:00040358550000510.5152/turkjsurg.2017.3337