Sayin, KubraGunes, Eda2024-02-232024-02-2320221540-75352641-452Xhttps://doi.org/10.37290/ctnr2641-452X.20:84-89https://hdl.handle.net/20.500.12452/16015Consumption of vinegar has been associated with protection against hyperglycemia, dyslipidemia, and hypertension. Hawthorn is a medicinal plant with hypolipidemic, anti-inflammatory, digestive modulator, antimicrobial, antioxidant, cardiac stimulant, and hypotensive properties. Therefore, Hawthorn vinegar rich in bioactives (epicatechin, triterpene, saponins, oligomeric procyanidins, chlorogenic acid, and flavonoids) may present a greater value as a functional food for the management of lifestyle diseases. Drosophila melanogaster, when placed on a high-fat diet, exhibit decreased life span and increased antioxidant enzymes. In this high-fat diet fly model, the Hawthorn vinegar led to a significant increase in mean life span, antioxidant enzyme activities, and reduction in malonyldialdehyde level. Furthermore, in vitro studies showed inhibition of alpha-glucosidase and alpha-amylase, and angiotensin-converting enzyme II activities, the measures of antiglycemic and antihypertensive potentials, respectively.eninfo:eu-repo/semantics/closedAccessAngiotensin-Converting EnzymeAnti-Atherogenic ActivityAntioxidant ActivityDrosophila MelanogasterHawthorn VinegarArticle20184892-s2.0-85126909820Q4WOS:000748366700011Q410.37290/ctnr2641-452X.20:84-89