Bitirgen, GulfidanBelviranli, SelmanMalik, Rayaz A.Kerimoglu, HurkanOzkagnici, Ahmet2024-02-232024-02-2320171120-67211724-6016https://doi.org/10.5301/ejo.5000910https://hdl.handle.net/20.500.12452/16863Purpose: To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. Methods: Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the PRP-treated eyes were compared with those of the fellow unaffected eyes. Results: The mean age of patients was 63.5 +/- 10.7 years (range 45-85 years). The mean nerve fiber density (NFD), nerve branch density, and nerve fiber length (NFL) were significantly lower in PRP-treated eyes compared with fellow eyes (p<0.001 for all). Average peripapillary RNFL thickness was significantly lower in PRP-treated eyes than in fellow eyes (p = 0.007). The NFD and NFL showed a modest but significant positive correlation with average peripapillary RNFL thickness (r = 0.310, p = 0.013 and r = 0.272, p = 0.030, respectively). conclusions: Significant reductions in corneal SBNP parameters and average peripapillary RNFL thickness were observed in the eyes of patients receiving PRP for the treatment of ischemic CRVO.eninfo:eu-repo/semantics/closedAccessCorneaIn Vivo Confocal MicroscopyPanretinal PhotocoagulationRetinal Nerve Fiber LayerSub-Basal Nerve PlexusArticle275591595281277352-s2.0-85028700827Q2WOS:000415309800018Q310.5301/ejo.5000910