İnkaya, Ahmet ÇağkanTürk Arıbaş, EmelErayman, İbrahimKandemir, BaharAcar, HasanBitirgen, Mehmet2020-01-182020-01-182019Erayman, İ., Kandemir, B., Acar, H., İnkaya, A. Ç., Türk Arıbaş, E., Bitirgen, M. (2019). Association of tumor necrosis factor alpha -238g/a and -308g/a promotor polymorphisms with clearance of hepatitis b virus ınfection in turkish population. Acta Medica, 50, 1, 1-6.2147-9488https://app.trdizin.gov.tr/makale/TXpFME1qQXhNUT09/association-of-tumor-necrosis-factor-alpha-238g-a-and-308g-a-promotor-polymorphisms-with-clearance-of-hepatitis-b-virus-infection-in-turkish-populationhttps://hdl.handle.net/20.500.12452/2743Objectives: Acute viral hepatitis B may lead to chronic hepatitis in 6% of adultpopulation. We compared the frequency of Tumor necrosis factor alpha promotor polymorphisms in chronic hepatitis B patients and people with natural immunity against hepatitis B.Materials and Methods: Chronic hepatitis B patients and age matched control cases with natural immunity to hepatitis B virus were recruited 1:1 in this study. Tumornecrosis factor alpha -238G/A and -308G/A polymorphisms were studied withPCR-RFLP. ?2 test was performed in statistical analysis.Results: A total of 101 volunteers enrolled in two study groups. Thirty-eight menand 12 women constituted the chronic hepatitis B patient group and 40 men and11 women recruited in natural immunity group. Frequency of -238G allele was87.5% and 97% in chronic hepatitis B and natural immunity groups, respectively.Frequency of -308G allel was 93% and 92.1% in chronic hepatitis B and natural im-munity groups, respectively. Frequencies of polymorphisms at positions -238 and-308 in the promotor of tumor necrosis factor alpha gene were not different be-tween chronic hepatitis B and natural immunity groups.Discussion: Tumor necrosis factor alpha promoter polymorphisms at -238 and-308 positions do not effect the outcome hepatitis B infection in Turkish population. Clearance of hepatitis B virus infection is multifactorial. Thus, further studiesneeded to identify genetic predisposition to chronic hepatitis B infection.eninfo:eu-repo/semantics/openAccessAcil TıpHepatitis B virusTumor necrosis factor alpha promoter polymorphismGenetic predisposition to chronic hepatitis B infectionArticle50116