Uysal, ŞengülCeylan, RamazanAbdurrahman , AktumsekGüler, Gökalp ÖzmenPicot, CareneZengin, Gökhan2020-01-182020-01-182018Uysal, Ş., Ceylan, R., Aktümsek, A., Güler, G. Ö., Picot, C., Zengin, G., Mahomoodally, M. F. (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy, 48, 1, 18-22.2548-07312587-2087https://dx.doi.org/10.5152/IstanbulJPharm.2018.396764https://app.trdizin.gov.tr/makale/TXpFd05qUXdNQT09/in-vitro-multiple-pharmacological-targets-of-colutea-cilicica-boiss-balansa-against-key-enzymes-linked-to-neurodegenerative-diseases-diabetes-and-hyperpigmentationhttps://hdl.handle.net/20.500.12452/2848WOS:000433052800004Prevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentationusing medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicicaBoiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerativediseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, ?-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C.cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamineequivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potentialfor ?-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for ?-amylase (0.57–0.12 mmol ACAE/gextract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl)and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract,respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract)was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respectiveextracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be usedagainst common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.eninfo:eu-repo/semantics/openAccessColutea cilicaAlzheimer’s diseased-Diabetes mellitusNatural agentsPhytopharmaceuticalsArticle4811824WOS:00043305280000410.5152/IstanbulJPharm.2018.396764