Aksoy, FarukGündeş, EbubekirVatansev, CelalettinÇakır, MuratToy, HaticeEmlik, Ganime Dilek2020-01-182020-01-182014Aksoy, F., Gündeş, E., Vatansev, C., Çakır, M., Toy, H., Emlik, G. D. (2014). Primary neuroendocrine carcinoma of the breast: a report of three cases. Meme Sağlığı Dergisi, 10, 2, 125-128.1306-0945https://app.trdizin.gov.tr/makale/TVRnMk56RXlNZz09/primary-neuroendocrine-carcinoma-of-the-breast-a-report-of-three-caseshttps://hdl.handle.net/20.500.12452/1402Primary neuroendocrine carcinoma of the breast is extremely rare. More than 97% of neuroendocrine tumors occur in the gastrointestinal and respiratory tracts. Three cases that have been operated in our clinic and had a diagnosis of primary neuroendocrine carcinoma of the breast were assessed, along with literature data. Histopathological diagnoses were obtained by preoperative core needle biopsy. Breast-conserving surgery was performed in two cases, and modified radical mastectomy in one. In all cases, immunohistochemical studies were positive for neuron-specific enolase and synaptophysin. All patients received adjuvant chemotherapy (CT) and one patient received additional radiotherapy (RT). Recurrence or distant metastasis was not detected during long-term follow-up after surgery.Memenin primer nöroendokrin karsinomları oldukça nadirdir. Nöroendokrin tumorlerin %97’den fazlası gastrointestinal ve solunum sisteminde ortaya çıkar. Kliniğimizde memenin primer nöroendokrin karsinomu nedeniyle opere edilen üç olgu literatür eşliğinde değerlendirildi. Ameliyat öncesi histopatolojik tanılar kalın iğne biyopsisi ile kondu. İki olguya meme koruyucu cerrahi, birine de modifiye radikal mastektomi işlemi uygulandı. Tüm olgularda immünhistokimyasal çalışmalarda nöron spesifik enolaz ve sinaptofizin pozitifliği görüldü. Olguların tümüne adjuvan tedavide kemoterapi (KT) verilmiş olup bir olguda ayrıca radyoterapi (RT) uygulandı. Ameliyat sonrası uzun dönem takiplerinde nüks ya da uzak metastaz saptanmadı.eninfo:eu-repo/semantics/openAccessMastectomyBreast CancerCarcinomaNeuroendocrineMastektomiMeme kanseriKarsinomNöroendokrinArticle102125128WOS:00021856080001110.5152/tjbh.2014.1557