Daye, MuniseTemiz, Selami Aykut2024-02-232024-02-2320202146-65052147-1894https://doi.org/10.4274/jarem.galenos.2019.2444https://hdl.handle.net/20.500.12452/16384Dapsone is an aniline derivative from synthetic sulfones. The mechanism of action of dapsone is obscure in inflammatory diseases; however, it is suggested to inhibit neutrophil chemotaxis and lysosomal enzymes. Acne vulgaris (AV) is a chronic inflammatory disorder of the pilo-sebaceous unit. Herein we report a pediatric patient who was started systemic isotretionin due to severe nodular cystic AV but could not continue due to elevated liver enzymes and well response to systemic dapsone treatment. We consider that per-oral dapsone treatment may be a well-tolerated and effective treatment option in patients with moderate/severe, frequently recurring AV which is irresponsive to conventional therapies and may a good alternative to isotretionin particularly in pediatric cases.eninfo:eu-repo/semantics/openAccessDapsoneIsotretinoinNodulocytic AcneArticle101103105WOS:00053089500002010.4274/jarem.galenos.2019.2444