Annagur, AliOrs, RahmiAltunhan, HuseyinKurban, SevilErtugrul, SabahattinKonak, MuratUygun, Saime Sunduz2024-02-232024-02-2320151328-80671442-200Xhttps://doi.org/10.1111/ped.12557https://hdl.handle.net/20.500.12452/14023BackgroundParaoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. MethodsA total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. ResultsIn the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). ConclusionLow serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.eninfo:eu-repo/semantics/closedAccessNeonatal SepsisOxidative Stress IndexParaoxonase-1Total Antioxidant StateTotal Oxidant StateArticle574608613254884112-s2.0-84940475437Q3WOS:000360501500017Q410.1111/ped.12557