Erdem, Said SamiToker, AysunKayrak, MehmetCicekler, HumeyraGonulalan, GulsumAbdulhalikov, TuryanYerlikaya, Fatma Humeyra2024-02-232024-02-2320150973-39301998-3832https://doi.org/10.1007/s13410-013-0185-4https://hdl.handle.net/20.500.12452/11456The aim of our study was to evaluate serum paraoxonase (PON1), total antioxidant status (TAS), total oxidant status (TOS), and ischemia-modified albumin (IMA) levels in patients with prediabetes, diabetes, and in healthy control subjects. The subjects were aged between 20 and 60 years. Forty diabetic subjects (mean age 46.6 +/- 9.7 years), 39 prediabetic subjects (mean age 44.0 +/- 9.3 years) and 24 healthy control subjects (mean age 43.7 +/- 9.7 years). Lipid profile, PON1, TAS, TOS and IMA levels were measured. The serum TOS and IMA levels in diabetes were significantly higher than those of the control subjects (P=0.024 and P=0.012, respectively), while the serum PON1 levels of the diabetes patients were significantly lower than those of the control subjects (P=0.039). The serum TOS levels of the diabetes patients were significantly higher than those of the subjects with prediabetes (P=0.013). There were no significant differences between the serum IMA and PON1 levels of the prediabetes and diabetes groups (P=0.075 and P=0.110, respectively). The serum TAS levels of the three groups were similar. The present study demonstrated that in diabetes there is greater oxidative stress. Patients with type 2 diabetes had higher TOS and IMA levels, but lower PON1 values, than controls. There were no differences in oxidative stress markers between prediabetic patients and healthy subjects.eninfo:eu-repo/semantics/closedAccessTotal Antioxidant StatusTotal Oxidant StatusIschemia-Modified AlbuminParaoxonasePrediabetesArticle35S465S4702-s2.0-84953250730Q3WOS:000411020700030Q410.1007/s13410-013-0185-4