Onk, DidemAyazoglu, Tulin AkarsuOnk, Oruc AlperAksut, MehmetGunay, MuratTurkmen, KultiginOzensoy, Aynur2024-02-232024-02-2320162314-61332314-6141https://doi.org/10.1155/2016/3272530https://hdl.handle.net/20.500.12452/14230Introduction. Increased levels of stress hormones are associated with mortality in patients undergoing coronary artery bypass grafting (CABG). Aim. To compare total intravenous anaesthesia (TIVA) and desflurane added to a subanaesthetic dose of propofol. Material and Methods. Fifty patients were enrolled in this study. Fentanyl (3-5mcg/kg/h) was started in both groups. Patients were divided into two groups. The PD group (n = 25) received 1 minimum alveolar concentration (MAC) desflurane anaesthesia in addition to propofol infusion (2-3 mg/kg/h), while P group (n = 25) received propofol infusion (5-6 mg/kg/h) only. Biochemical data, cortisol, and insulin levels were measured preoperatively (T0), after initiation of CPB but before cross-clamping the aorta (T1), after removal of the cross-clamp (T2), and at the 24th postoperative hour (T3). Results. Systolic, diastolic, and mean arterial pressure levels were significantly higher in PD group than those in P group in T1 and T2 measurements (p <= 0.05). CK-MB showed a significant decrease in group P (p <= 0.05). When we compared both groups, cortisol levels were significantly higher in PD group than P group (p <= 0.05). Conclusion. Stress and haemodynamic responses were better controlled using TIVA than desflurane inhalation added to a subanaesthetic dose of propofol in patients undergoing CABG.eninfo:eu-repo/semantics/openAccess[Keyword Not Available]Article2016275477572-s2.0-85006150306Q2WOS:000381150500001Q210.1155/2016/3272530