Bilgic, AyhanSivri, Rukiye ColakKilinc, Ibrahim2024-02-232024-02-2320180803-94881502-4725https://doi.org/10.1080/08039488.2018.1484512https://hdl.handle.net/20.500.12452/13089Purpose: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD.Materials and methods: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale. The severity of anxiety levels was determined through the Screen for Child Anxiety-Related Emotional Disorders. Plasma levels of 8-F2-isoprostane, Trx, and TrxR were measured using commercial enzyme-linked immunosorbent assay kits.Results: Plasma 8-F2-isoprostane, Trx, and TrxR levels did not show any significant differences between patient and control groups. There were no significant correlations between plasma levels of these antioxidants and severity of OCD.Conclusions: Findings of this study did not support the involvement of oxidative stress in the etiology of childhood OCD.eninfo:eu-repo/semantics/closedAccessObsessive-Compulsive Disorder8-F2-IsoprostaneThioredoxinThioredoxin ReductaseChildrenArticle727484488299276772-s2.0-85048753803Q2WOS:000456435500005Q210.1080/08039488.2018.1484512