Demir, AliBıyık, MuratBuğdacı, Mehmet SaitKorkmaz, HüseyinTemel, TuncerGöktürk, Hüseyin SavaşÖzakyol, AyşegülHatemi, İbrahimBaysal, BirolKaraca, ÇetinŞentürk, Hakan2020-01-182020-01-182014Demir, A., Bıyık, M., Buğdacı, M. S., Korkmaz, H., Temel, T., Göktürk, H. S., Özakyol, A., Hatemi, İ., Baysal, B., Karaca, Ç., Şentürk, H. (2014). Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C. Turkish Journal of Gastroenterology, 25, 5, 539-545.1300-49482148-5607https://app.trdizin.gov.tr/makale/TWpJeE1qYzFOUT09/routinely-evaluated-clinical-assays-and-laboratory-tests-real-test-and-fibrosis-stages-of-chronic-hepatitis-b-and-chttps://hdl.handle.net/20.500.12452/1332Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45±13/years [emale/male (F/M)47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52±cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be <1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)0.852, 95% CI:0.820.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be <1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC:0.95, 95% CI:0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.eninfo:eu-repo/semantics/openAccessChronic hepatitisREAL TESTRoutine laboratory testsFibrosisRoutinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and CArticle255539545Q3WOS:000345023700012Q410.5152/tjg.2014.6170