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dc.contributor.authorSavdan, Mervan
dc.contributor.authorÇakir, Murat
dc.contributor.authorHüsamettin , Vatansev
dc.contributor.authorKüçükkartallar, Tevfik
dc.contributor.authorTekin, Ahmet
dc.contributor.authorTavli, Şakir
dc.date.accessioned2020-01-18T21:12:16Z
dc.date.available2020-01-18T21:12:16Z
dc.date.issued2017
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.urihttps://dx.doi.org/10.5152/turkjsurg.2017.3337
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TWpJM05UazVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2739
dc.description.abstractObjective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen freeradicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), whichis a potent exogenous free-radical scavenger and antioxidant.Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of MedicineResearch and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino ratswere used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group(sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in thesecond group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastriclavage for 10 days in the third group.Results: Biochemical values revealed a statistically significant difference between Group I and the others. There wasno difference between Group II and III regarding biochemical values. There was a statistically significant difference,however, between Group II and III with regards to nitric oxide levels. There was a statistically significant differencebetween Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage.Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage causedby oxygen free-radicals.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5152/turkjsurg.2017.3337en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titlePreventing oxygen free radical damage by proanthocyanidin in obstructive jaundiceen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Surgeryen_US
dc.contributor.departmentNecmettin Erbakan Üniversitesien_US
dc.identifier.volume33en_US
dc.identifier.issue2en_US
dc.identifier.startpage62en_US
dc.identifier.endpage68en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]


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