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    Development of infusion tea formulations with food wastes: Evaluation of temperature and time effects on quality parameters
    (Elsevier, 2022) Acar, Aysenur; Aydin, Merve; Arslan, Derya
    The study aimed to investigate the suitability of some food wastes for use in the production of herbal tea and to reveal their properties in terms of bioactive component content, some physical properties and sensory quality. Three new blends consisting of banana, pomegranate, mandarin, eggplant and red onion peels, walnut shell, cherry stalk and corn tassel were infused at different temperatures (70 and 100 degrees C) and time (3, 4 and 5 min). Corn tassel tea, which has a high phenolic component content (677.7 mg GAE/L), received less sensory acceptance due to its bitter aftertaste. Therefore, walnut shell tea containing moderate phenolic content was the most preferred tea blend. Significant effects of different infusion temperatures and times on the color indices of teas were also demonstrated. The sensory properties of samples infused for 3 min were more acceptable. The highest correlation coefficients were calculated between total phenolic compounds and subjective odor parameters. Utilization of mandarin, pomegranate, banana, eggplant and red onion peels, walnut shell, corn tassel and cherry stalk in formulating a functional and an alternative food product can be attractive to consumers and industrial producers due to their affordability and high bioactivity.
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    In vitro antifungal and antibiofilm activities of novel sulfonyl hydrazone derivatives against Candida spp.
    (Masson Editeur, 2023) Aydin, Merve; Ozturk, Ali; Duran, Tugce; Ozmen, Ummuhan Ozdemir; Sumlu, Esra; Ayan, Esra Bilen; Korucu, Emine Nedime
    Background: The aim of this study was to investigate the antifungal and antibiofilm activity of the new sulfo-nyl hydrazones compound derived from sulphonamides.Methods: In this study, new sulfonyl hydrazone series were synthesized via a green chemistry method. The structures of the synthesized compounds were characterized by elemental analyses and spectroscopic meth-ods. The antifungal activities of the Anaf compounds against Candida strains under planktonic conditions were tested. The biofilm-forming ability of Candida strains was determined and the inhibitory effects of Anaf compounds on Candida biofilms compared with fluconazole were measured by MTT assay. Expression analy-sis of biofilm-related genes was investigated with qRT-PCR. The statistical analysis was performed using a one-way ANOVA test.Candida: strains was determined and the inhibitory effects of Anaf compounds on Candida biofilms compared with fluconazole were measured by MTT assay. Expression analysis of biofilm-related genes was investigated with qRT-PCR. The statistical analysis was performed using a one-way ANOVA test. Results: A total of 16 (45.7%) out of 35 Candida isolates were determined as strong biofilm producers in this study. C. albicans was the most biofilm producer, followed by C. krusei and C. lusitaniae. The Anaf compounds had a broad spectrum of activity with MIC values ranging from 4 mg/ml to 64 mg/ml. Our data indicated that the Anaf compound had a significant effect on inhibiting biofilm formation in both fluconazole-susceptible and-resistant strains. The expression levels of hypha-specific genes als3, hwp1, ece1 and sap5 were downre-gulated by Anaf compounds.Conclusions: Our study revealed that the Anaf compounds had antifungal activity and inhibited fungal bio-films, which may be related to the suppression of C. albicans adherence and hyphal formation. These results suggest that Anaf compounds may have therapeutic potential for the treatment and prevention of biofilm-associated Candida infections.(c) 2022 SFMM. Published by Elsevier Masson SAS. All rights reserved.
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    The Relationship between Serum Oxalic Acid, Central Hemodynamic Parameters and Colonization by Oxalobacter formigenes in Hemodialysis Patients
    (Karger, 2015) Gulhan, Baris; Turkmen, Kultigin; Aydin, Merve; Gunay, Murat; Cikman, Aytekin; Kara, Murat
    Background/Objective: Elevated pulse wave velocity (PWV) and central aortic blood pressures are independent predictors of increased cardiovascular morbidity and mortality in hemodialysis (HD) patients. Oxalic acid is a uremic retention molecule that is extensively studied in the pathogenesis of calcium oxalate stones. Oxalobacter formigenes, a member of the colon microbiota, has important roles in oxalate homeostasis. Data regarding the colonization by and the exact role of Oxalobacter formigenes in the pathogenesis of oxalic acid metabolism in HD patients are scant. Hence, we aimed to determine the relationship between fecal Oxalobacter formigenes colonization, serum oxalic acid and hemodynamic parameters in HD patients with regard to the colo-reno-cardiac axis. Methods: Fifty HD patients were enrolled in this study. PWV and central aortic systolic (cASBP) and diastolic blood pressures (cADBP) were measured with a Mobil-O-Graph (I.E.M. GmbH, Stolberg, Germany). Serum oxalic acid levels were assessed by ELISA, and fecal Oxalobacter formigenes DNA levels were isolated and measured by real-time PCR. Results: Isolation of fecal Oxalobacter formigenes was found in only 2 HD patients. One of them had 113,609 copies/ml, the other one had 1,056 copies/ml. Serum oxalic acid levels were found to be positively correlated with PWV (r = 0.29, p = 0.03), cASBP (r = 0.33, p = 0.001) and cADBP (r = 0.42, p = 0.002) and negatively correlated with LDL (r = -0.30, p = 0.03). In multivariate linear regression analysis, PWV was independently predicted by oxalic acid, glucose and triglyceride. Conclusions: This is the first study that demonstrates the absence of Oxalobacter formigenes as well as a relation between serum oxalic acid and cASBP, cADBP and PWV in HD patients. Replacement of Oxalobacter formigenes with pre- and probiotics might decrease serum oxalic acid levels and improve cardiovascular outcomes in HD patients. (C) (C) 2015 S. Karger AG, Basel
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    THE RELATIONSHIP BETWEEN SERUM OXALIC ACID, CENTRAL HEMODYNAMIC PARAMETERS AND COLONIZATION OF OXALOBACTER FORMIGENES IN HEMODIALYSIS PATIENTS: FROM IMPAIRED COLON TO IMPAIRED AORTA
    (Oxford Univ Press, 2015) Gulhan, Baris; Turkmen, Kultigin; Aydin, Merve; Gunay, Murat; Cikman, Aytekin; Kara, Murat
    [Abstract Not Availabe]
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    Subtype distribution and molecular characterization of Blastocystis from hemodialysis patients in Turkey
    (J Infection Developing Countries, 2020) Gulhan, Baris; Aydin, Merve; Demirkazik, Mehtap; Koltas, Ismail Soner; Cikman, Aytekin; Turkmen, Kultigin; Duran, Tugce
    Introduction: The aim of this study was to determine the Blastocystis prevalence and subtypes in hemodialysis patients in Turkey. Methodology: Eighty-four patients diagnosed with end-stage renal failure who were undergoing hemodialysis and 20 healthy volunteers were enrolled. Blastocystis presence was investigated by native-Lugol, trichrome staining, PCR using STS primers, and DNA sequencing analysis. Results: Among the stool samples from the hemodialysis patients, 9.52% (8/84) were found to be Blastocystis-positive with the native-Lugol and trichrome staining. Seven of the eight Blastocystis isolates were subtyped using STS primers. Blastocystis subtype distribution was as follows: one had ST1, two had ST2, two had ST3, two had ST3+ST6, and one was not subtyped. Blastocystis positivity was detected in two healthy control (2/20, %10), one subject had ST1, and the other was not subtyped. All subtypes identified by PCR were confirmed by the sequencing analysis. In the two samples that had mixed subtypes (ST3+ST6) when using the STS primers, only ST3 was detected in the sequencing analysis. Although some patients have multiple symptoms, the most common symptoms in Blastocystis positive patients were bloating (5/8), diarrhea (4/8), nausea and vomiting (2/8), and gas and weight loss (1/8). Also, only one patient had Giardia intestinalis. Conclusions: This was the first study to determine the Blastocystis subtypes in hemodialysis patients. A rare subtype, ST6, was identified in two of the patients. Thus, the ST6 infections were attributable to transmission from poultry infections. The presence of this unusual subtype suggests the need for further extensive studies of hemodialysis patients.