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Öğe Single-step approach for synthesis of a novel tetracyclic skeleton: Investigation of X-ray analysis, fluorescence spectra, TD-DFT calculations and biological activities(Elsevier, 2023) Kuzu, Burak; Gül, Sergen; Tan Uygun, Meltem; Dönmez, Mesude Figen; Mengeş, NurettinTetracyclic molecules show important properties such as biological activities and fluorescence sensors. Hence, in this study, we have reported unknown tetracyclic skeleton. N -propargylated C-2 and C-4 disubstituted imidazole derivatives were reacted by 2-aminomethyl piperidine without using any transition metal. The reaction unveiled 16 different imidazo[1,2-a]pyrido[1 ' ,2 ' :3,4]imidazo[2,1-c]pyrazine skeletons. Cyclization reaction tolerated phenyl, naphthyl, bi-phenyl, 2-thienyl, and many substituents on the benzene ring such as OMe, CF 3 , and halogens. We have uncovered the exact structure of the tetracyclic skeleton using single-crystal X-ray analysis. Significant fluorescence emission of tetracyclic molecules was investigated, and derivatives bearing electron-withdrawing groups, CF 3 , and the 2-thienyl group possessed a bathochromic effect (shift to longer wavelength) which was confirmed by not only steady-state experiments but HOMOs and LUMOs calculations. The antimicrobial effects of the synthesized molecules on six different or ganisms were tested. Considerable activities of molecules 5p and 5n on many organisms were determined. Docking modeling and Lipinski, Ghose, and Veber compatibility studies of two different molecules were performed.Öğe D-A-D type functional conducting polymer: Development of its electrochromic properties and laccase biosensor(Wiley, 2023) Udum, Yasemin A.; Aktaş Gemci, Melek; Cevher, Duygu; Söylemez, Saniye; Çırpan, Ali; Toppare, LeventHerein, a novel D-A-D type monomer that contains hexylthiophene as the donor and benzo[c][1,2,5]thiadiazole as the acceptor has been electropolymerized successfully to yield P(DTFBT) and its electrochromic properties and performance in amperometric biosensors have been investigated. The polymer shows great electrochemical features with low band gap and multichromic properties. Additionally, after polymer modification, laccase was immobilized on a modified electrode surfaces for catechol sensing. Biosensor optimization values, cycle number, enzyme amount, pH and also interfering effect of some possible compounds were investigated. With optimum values, analytical characterization of the sensor was determined. Kmapp, LOD and sensitivity values were estimated as 0.11 mM, 0.014 mM and 166.74 mu A/(mM cm(2)), respectively. The experimental results revealed that the sensor shows satisfactory accuracy and confirms the proposed sensor has a potential candidate for catechol quantification.
