Evaluating the effect of tumor size and sidedness on prognosis in stage 2 colon cancer: a retrospective population study

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dc.contributor.authorDemir, H.
dc.contributor.authorCaglayan, D.
dc.contributor.authorKaman, O.
dc.contributor.authorInanc, M.
dc.contributor.authorUrvay, S.
dc.contributor.authorBeypinar, I
dc.contributor.authorDemirci, A.
dc.date.accessioned2024-02-23T14:49:31Z
dc.date.available2024-02-23T14:49:31Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: In this study. we aimed to evaluate the effect of tumor size and tumor sidedness on prognosis in patients with stage 2 colon cancer. PATIENTS AND METHODS: Data of 501 patients diagnosed with stage 2 colon cancer were evaluated retrospectively. It was evaluated whether the patients' age, gender, tumor differentiation, tumor node metastasis (TNM) stage, overall survival rate, and disease-free survival rate had any correlation with horizontal tumor diameter and tumor sidedness. In the ROC analysis performed to determine the cut-off value for the tumor diameter, which we think will predict survival, no significant results were obtained with maximum sensitivity and specificity. Therefore, the median value of the tumor diameter, which is 5 cm, was accepted as the cut-off value. Kaplan-Meier method and Cox regression analysis were used for survival analysis and determination of prognostic factors. RESULTS: When the patients were evaluated in terms of tumor localization, 189 (37.7%) patients had right colon tumors and 312 (62.3%) patients had left colon tumors. There was no statistically significant difference in terms of disease-free survival and overall survival according to tumor localization. When the patients were analyzed by dividing them into two groups according to the horizontal tumor size (<5 cm and >= 5 cm), no statistically significant difference was found between the groups in terms of disease-free survival (DFS) and overall survival (OS) p=0.085, p=0.699, respectively. CONCLUSIONS: Our results suggest that the management of patients with stage 2 colon cancer requires a better understanding of tumor biology rather than features such as tumor size and localization.en_US
dc.identifier.endpage1340en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid35253189en_US
dc.identifier.scopus2-s2.0-85125765328en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1328en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18242
dc.identifier.volume26en_US
dc.identifier.wosWOS:000763342100009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon Canceren_US
dc.subjectTumor Sizeen_US
dc.subjectTumor Sidednessen_US
dc.subjectPrognosisen_US
dc.titleEvaluating the effect of tumor size and sidedness on prognosis in stage 2 colon cancer: a retrospective population studyen_US
dc.typeArticleen_US

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