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  • Küçük Resim
    Öğe
    Melena Associated with Ganoderma Lucidum: A Case Report
    (2015) Acar, Demet; Gülpembe, Mustafa; Akıllı, Nazire Belgin; Göknil Çalık, Saniye; Köylü, Ramazan; Günaydın, Yahya Kemal; Cander, Başar
    Melena acil servis hastaları arasında görülen hayatı tehdit edebilecek bir bulgudur. Olgu Sunumu: Biz burada, önceden bilinen herhangi bir mide şikayeti olmayan genç bir erkek hastada Ganoderma Lucidum kullanımı ile indüklenen bir melena olgusu sunacağız. Sonuç: G. lucidum'un bazı toksik etkileri bildirilmiştir ancak bildiğimiz kadarıyla, bu vaka bildirilen G. lucidum ile ilişkili ilk üst gastrointestinal sistem kanamasıdır.
  • Küçük Resim Yok
    Öğe
    The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis: is there a dilemma?
    (Tubitak Scientific & Technological Research Council Turkey, 2017) Acar, Demet; Gulpembe, Mustafa; Yildiz, Can Gokay; Ozdamar, Emine Nur; Acikgoz, Kerem; Caglar, Ahmet; Cander, Basar
    Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250-300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin + crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (% 3) + mannitol + sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, and serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels were studied. Results: All parameters were statistically significantly higher in the control group than in the treatment groups at all hours. However, there was no statistically significant difference among treatment groups regarding any of the parameters. Conclusion: This is the first study determining the role of atorvastatin in the treatment of renal ischemia/reperfusion injury in a crush syndrome and rhabdomyolysis model setting. Larger studies with different atorvastatin doses are required to define the role of this drug in the treatment of renal ischemia/reperfusion injury during crush syndrome.
  • Küçük Resim
    Öğe
    The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?
    (2017) Acar, Demet; Gülpembe, Mustafa; Yıldız, Can Gökay; Özdamar, Emine Nur; Açıkgöz, Kerem; Çağlar, Ahmet; Cander, Başar
    Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) mannitol sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, and serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels were studied. Results: All parameters were statistically significantly higher in the control group than in the treatment groups at all hours. However, there was no statistically significant difference among treatment groups regarding any of the parameters. Conclusion: This is the first study determining the role of atorvastatin in the treatment of renal ischemia/reperfusion injury in a crush syndrome and rhabdomyolysis model setting. Larger studies with different atorvastatin doses are required to define the role of this drug in the treatment of renal ischemia/reperfusion injury during crush syndrome.
  • Küçük Resim
    Öğe
    Rhabdomyolysis Associated with Opiate Abuse: A Case Report
    (2015) Gülpembe, Mustafa; Acar, Demet; Akıllı, Nazire Belgin; Göknil Çalık, Saniye; Günaydın, Yahya Kemal; Köylü, Ramazan; Cander, Başar
    Opioid kötüye kullanımı ile ilişkili pek çok komplikasyon bildirilmiştir. Bunların arasında solunum depresyonu, bilinç bulanıklığı, aspirasyon ğnömonisi, pulmoner ödem, miyokardit, rabdomiyoliz ve kompartman sendromu sayılabilir. Bu komplikasyonların bazıları hayatı tehdit eder.Olgu Sunumu: Burada genç bir erkek hastada opioid kötüye kullanımına bağlı gelişen rabdomiyoliz vakası sunacağız. Sonuç: Rabdomiyoliz intravenöz opioid kötüye kullanımına bağlı nadir görülen bir komplikasyondur. Rabdomiyoliz hayatı tehdit edebilecek sonuçlar doğurabileceği için erken tanı ve tedavisi çok önemlidir. Bu nedenle klinisyenler opioid kullanıcılarında bu komplikasyona karşı uyanık olmalılardır.