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    Are the obsessive-compulsive traits a moderator for the relationship between autism and anorexia? A cross-sectional study among university students
    (Routledge Journals, Taylor & Francis Ltd, 2022) Acikel, S. Burak; Cikili, Yahya
    Objective It is known that there is a high comorbidity between eating disorders and autistic traits among both the clinical and non-clinical populations. In this study, it is aimed to investigate the relationship between ASD and AN, and the effects of obsessive-compulsive traits. Participants: The study has been conducted in a non-clinical sample. A total of 290 university students have been included. Methods: Autism Quotient (AQ), Eating Attitudes Test (EAT) and Maudsley Obsessive-Compulsive Inventory (MOCI) have been used. Results: There is a positive relationship between EAT-40, MOCI scores, and AQ total scores. However, after controlling the sex and MOCI scores relation in total AQ and EAT-40 scores, they have become statistically insignificant. In regression, only MOCI scores and AQ Communication subscale scores have been able to predict the EAT-40 scores. Conclusions: It has been found that the relationship between autistic traits and eating attitudes is moderated by obsessive-compulsive traits.
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    The association between leptin receptor polymorphism and suicidal behaviour in depressed adolescents
    (Taylor & Francis Ltd, 2020) Acikel, S. Burak; Eroglu, Canan; Dikmen, Asiye Ugras; Kurar, Ercan
    Objective: Suicide is the second leading cause of death in adolescence. Genetic studies implicate the genetic component of suicide independent from associated psychiatric disorder. Although genetics is an important factor that might be associated with suicide, limited progress is achieved to identify the candidate genes in adolescents. Methods: The study included 97 patients and 106 controls. Five leptin receptor single nucleotide polymorphism (SNP) region examined. Depressive scores were measured with Children Depression Inventory and suicidal behaviour was measured by Suicide Probability Scale. Logistic and linear regression analysis used for determining to predictors. Results: In linear regression analysis (R-2: 0.786) both previous suicide attempt (B:5.553, t:2.613 p: .035) and having a mutant allele in rs1171276 SNP region (B:4.346 t:2.220 p: .048) have been associated with suicidal behaviour. In logistic regression analysis, family history of depression (p < .0001, OR: 4.2 [1.7-9.6]) and number of stressful life events (p: .001, OR: 1.7 [1.3-2.1]) predicted depression significantly. Conclusion: Leptin receptor polymorphism could result in an increase in impulsive behaviour and suicide scores with leptin resistance. Our research is the first study to investigate the relationship between depression, suicidal behaviour and leptin receptor polymorphism in adolescent sample. Similar studies could be carried out on a community basis.