Yazar "Akca, Omer Faruk" seçeneğine göre listele
Listeleniyor 1 - 20 / 40
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe ADHD symptoms, breast-feeding and obesity in children and adolescents(Wiley, 2015) Turkoglu, Serhat; Bilgic, Ayhan; Akca, Omer FarukBackgroundAttention-deficit-hyperactivity disorder (ADHD) has been found to be related to overweight/obesity in children and adolescents, but it is a heterogeneous disorder, and the relationships between the dimensions of ADHD and overweight/obesity are not clear. The aim of this study was to explore which dimensions of the disorder are specifically associated with overweight/obesity. MethodsThe study sample consisted of 300 treatment-naive children with ADHD and 75 healthy controls aged 7-17 years. The ADHD module of the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to diagnose ADHD. The severity of ADHD symptoms was assessed via Conners' Parent Rating Scale (CPRS). The weight, height, and breast-feeding duration of the study samples and controls were recorded. Body mass index (BMI) was categorized according to the national age/sex-specific reference values. ResultsThe rate of overweight/obese children was higher in the ADHD group. The association between ADHD symptoms and BMI percentile scores was evaluated using structural equation modeling. In that model, it was observed that the Cognitive Problems/Inattentive and Oppositional subscores of the CPRS had a positive predictive effect on the BMI percentile scores, but breast-feeding duration had a negative predictive effect on the BMI percentile scores. ConclusionInattention, oppositionality and breast-feeding duration were associated with overweight/obesity in children and adolescents with ADHD. Longitudinal studies are needed to more fully understand this relationship and the mechanisms underlying the association between ADHD and overweight/obesity.Öğe Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder(Taylor & Francis Ltd, 2022) Bilgic, Ayhan; Abusoglu, Sedat; Sadic celikkol, Cagla; Oflaz, Mehmet Burhan; Akca, Omer Faruk; Sivrikaya, Abdullah; Baysal, TamerAim There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. Materials and Methods A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Results Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. Conclusions These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.Öğe Anxiety sensitivity: changes with puberty(Springer, 2013) Akca, Omer Faruk; Vural, Tuba Agac; Turkoglu, Serhat; Kilic, Emine Zinnur[Abstract Not Availabe]Öğe Anxiety sensitivity: Changes with puberty and cardiovascular variables(Wiley, 2015) Akca, Omer Faruk; Vural, Tuba Agac; Turkoglu, Serhat; Kilic, Emine ZinnurBackgroundAnxiety sensitivity (AS) is a relatively stable dispositional variable that may increase the risk for anxiety-related symptoms, particularly panic attack, among individuals of all age groups. Changes in AS during adolescence in healthy individuals, however, has not been previously investigated. The aim of this study was therefore to investigate the relationship of AS with puberty level, pulse rate, and blood pressure in healthy adolescents. MethodsThe sample consisted of 133 healthy adolescents (70 boys, 63 girls) aged 10-17 years. Puberty stage (i.e. Tanner stage), pulse rate, and blood pressure of each participant were determined. The Childhood Anxiety Sensitivity Inventory was used to identify AS. The correlations between AS and the clinical variables were assessed. ResultsAS was negatively correlated with pubertal stage when age and gender were controlled. Also, AS was correlated with diastolic blood pressure when age, gender, and pubertal stage were controlled (P < 0.05). Neither systolic blood pressure nor heart rate were correlated with AS. ConclusionAS, which is reported to be a trait-like variable, may change during adolescence, due to the effect of pubertal growth and blood pressure interacting with AS during adolescence.Öğe Aripiprazole in the Treatment of Obsessive Compulsive Disorder and Aggressive Behaviors in a Child With Prader Willi Syndrome: A Case Report(Lippincott Williams & Wilkins, 2016) Akca, Omer Faruk; Yilmaz, Savas[Abstract Not Availabe]Öğe Aripiprazole Treatment in a 9-Year-Old Child With OCD and Hypomania Symptoms Possibly Related to Herbal Medicines A Case Report(Lippincott Williams & Wilkins, 2018) Celikkol, Cagla; Akca, Omer Faruk[Abstract Not Availabe]Öğe Aripiprazole Treatment of Compulsive Behaviors Associated With Methylphenidate in a Child With Down Syndrome(Lippincott Williams & Wilkins, 2018) Sertdemir, Merve; Akca, Omer Faruk[Abstract Not Availabe]Öğe Borderline personality disorder and attention deficit/hyperactivity disorder in adolescence: overlap and differences in a clinical setting(Bmc, 2020) Akca, Omer Faruk; Wall, Kiana; Sharp, CarlaBackground With increased consensus regarding the validity and reliability of diagnosing Borderline Personality Disorder (BPD) in adolescents, clinicians express concern over the distinction between BPD and Attention-Deficit/Hyperactivity Disorder (ADHD), and its co-morbidity in clinical settings. The goal of this study was to evaluate differences between BPD, ADHD and BPD + ADHD in terms of co-morbid psychiatric disorders and a range of self-reported behavioral problems in adolescents. Methods Our sample consisted of N = 550 inpatient adolescents with behavioral and emotional disorders that have not responded to prior intervention. We took a person-centered approach (for increase clinical relevance) and compared adolescents with ADHD, BPD and ADHD+BPD in terms of co-occurring psychiatric disorders and behavioral problems. We performed a regression analysis to test whether BPD symptoms make an incremental contribution to the prediction of psychiatric symptoms over ADHD symptoms. Results The severity of almost all co-occurring disorders, aggression, self-harm, suicidal thoughts, and substance use, were higher in the ADHD+BPD group. Borderline symptoms made an incremental contribution to the prediction of psychiatric symptoms beyond the contribution of ADHD. Conclusion Severity and co-morbidity may be helpful factors in distinguishing between ADHD and BPD in clinical practice and the co-morbidity of these two disorders may indicate a worse clinical outcome.Öğe Borderline personality disorder and attention deficit/hyperactivity disorder in adolescence: overlap and differences in a clinical setting(Bmc, 2020) Akca, Omer Faruk; Wall, Kiana; Sharp, CarlaBackground With increased consensus regarding the validity and reliability of diagnosing Borderline Personality Disorder (BPD) in adolescents, clinicians express concern over the distinction between BPD and Attention-Deficit/Hyperactivity Disorder (ADHD), and its co-morbidity in clinical settings. The goal of this study was to evaluate differences between BPD, ADHD and BPD + ADHD in terms of co-morbid psychiatric disorders and a range of self-reported behavioral problems in adolescents. Methods Our sample consisted of N = 550 inpatient adolescents with behavioral and emotional disorders that have not responded to prior intervention. We took a person-centered approach (for increase clinical relevance) and compared adolescents with ADHD, BPD and ADHD+BPD in terms of co-occurring psychiatric disorders and behavioral problems. We performed a regression analysis to test whether BPD symptoms make an incremental contribution to the prediction of psychiatric symptoms over ADHD symptoms. Results The severity of almost all co-occurring disorders, aggression, self-harm, suicidal thoughts, and substance use, were higher in the ADHD+BPD group. Borderline symptoms made an incremental contribution to the prediction of psychiatric symptoms beyond the contribution of ADHD. Conclusion Severity and co-morbidity may be helpful factors in distinguishing between ADHD and BPD in clinical practice and the co-morbidity of these two disorders may indicate a worse clinical outcome.Öğe Buspirone in the Treatment of Fluoxetine-Induced Sleep Bruxism(Mary Ann Liebert, Inc, 2016) Sivri, Rukiye Colak; Akca, Omer Faruk[Abstract Not Availabe]Öğe CAREGIVER BURDEN AND RELATED FACTORS IN MOTHERS OF CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS(Elsevier Science Inc, 2016) Akca, Omer Faruk; Uzun, Necati; Pekcan, Sevgi; Akkus, Erkan; Gulec, Kemal[Abstract Not Availabe]Öğe Children with Migraine and Those with Tension-Type Headache for Psychiatric Symptoms and Quality of Life (vol 19, pg 14, 2021)(Georg Thieme Verlag Kg, 2021) Acikel, Sadettin Burak; Bilgic, Ayhan; Derin, Hatice; Eroglu, Arzu; Akca, Omer Faruk; Caksen, Huseyin[Abstract Not Availabe]Öğe Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder(Elsevier Espana Slu, 2024) Ferahkaya, Hursit; Akca, Omer Faruk; Baysal, Tamer; Kilinc, IbrahimBackground and objectives: Accumulating studies have pointed out that gut-blood and blood -brain barrier dysfunctions due to the alterations in permeability may play a role in the patho-physiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.Methods: A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.Results: Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.Conclusion: These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.(c) 2023 Sociedad Espanola de Psiquiatna y Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Comparison of Children with Migraine and Those with Tension-Type Headache for Psychiatric Symptoms and Quality of Life(Georg Thieme Verlag Kg, 2021) Acikel, Burak Sadettin; Bilgic, Ayhan; Derin, Hatice; Eroglu, Arzu; Akca, Omer Faruk; Caksen, HuseyinThis study compared the severity of depression, anxiety, somatization, anxiety sensitivity, sleep disturbances, and quality of life (QoL) among children with migraine, children with tension-type headache (TTH), and healthy children. A total of 37 children with migraine, 22 with TTH, and a healthy control group (n =35) participated in this study. Children with migraine exhibited higher depression and somatization and lower QoL scores than those in the control group. General sleep disturbances, bedtime resistance, sleep onset delay, sleep duration, sleep anxiety, night wakings, sleep-disordered breathing, and daytime sleepiness scores were also higher in those in the migraine group than in the control group. Regression models indicated that the severity of headache and depression scores significantly affected the QoLs of children with headache disorder as a whole. Migraine is associated with depression, somatization, sleep disturbances, and poor QoL, whereas TTH is associated with only sleep disturbances in childhood. The impact of headache on the QoL occurs mainly through the headache-specific and psychiatric factors.Öğe Decreased plasma intercellular adhesion molecule-3 levels are associated with obsessive compulsive disorder in medication-free children(Elsevier, 2020) Bilgic, Ayhan; Ileri, Betul Akbas; Kilinc, Ibrahim; Akca, Omer FarukThe objective of this study was to evaluate whether the plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), intercellular adhesion molecule-3 (sICAM-3), vascular cell adhesion molecule-1 (sVCAM-1), and/or platelet endothelial cell adhesion molecule-1 (sPECAM-1) were associated with obsessive compulsive disorder (OCD) in childhood. A total of 42 (25 boys, 17 girls) medication-free children with OCD and 38 (18 boys, 20 girls) healthy controls aged 8-18 years were included in the study. The severity of the OCD symptoms was assessed using the Children's Yale-Brown Obsessive Compulsive Scale. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were used to measure the children's depression and anxiety levels. The sICAM-1, sICAM-3, sVCAM-1, and sPECAM-1 concentrations were measured using an enzyme-linked immunosorbent assay. A multivariate analysis of covariance revealed a significant main effect on both groups in terms of the concentrations of plasma adhesion molecules, which was independent of the severities of depression and anxiety, body mass index percentile, age, and sex. An analysis of covariance showed that plasma sICAM-3 concentrations were significantly lower in the OCD group than in the control group. These data suggest that sICAM-3 may play a role in the etiopathogenesis of OCD in children.Öğe Divergent mentalization types in adolescent borderline personality disorder and attention deficit/hyperactivity disorder(Taylor & Francis Ltd, 2021) Akca, Omer Faruk; Wall, Kiana; Sharp, CarlaBackground Attention deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) have several similarities and it is difficult to distinguish these disorders in adolescents. We aimed to identify the unique correlates of mentalization abilities that may distinguish these two disorders, and to investigate the mentalization abilities of adolescents with ADHD, BPD and ADHD + BPD in an inpatient sample to determine the effect of co-morbidity on mentalization abilities. Methods We have explored the relationship between Child Eye Test (CET) scores, Movie for the Assessment of Social Cognition (MASC) subscales, and ADHD and BPD symptoms in adolescent inpatients. In addition, we compared ADHD, BPD and ADHD + BPD groups in terms of their mentalization abilities. Results Correct MASC scores were negatively associated with both ADHD and BPD symptoms in girls, and negatively associated with ADHD symptoms in boys. In addition, hypermentalization scores were associated with BPD symptoms in girls, and hypomentalization and no mentalization scores were associated with ADHD symptoms in girls. CET scores were negatively associated with ADHD symptoms in girls, but no relations with BPD were found. Group comparisons revealed no significant difference among groups. Limitations We included only inpatient sample without considering their medication condition, we did not compare the mentalization scores of the patient groups with healthy controls and we used self-report measures for several assessments. Conclusion Mentalization patterns in ADHD and BPD are distinct. ADHD may be related to hypomentalization, instead, BPD may be related to hypermentalization.Öğe Effectiveness of Low-Dose Aripiprazole Monotherapy in the Treatment for an Adolescent With Obsessive-Compulsive Disorder(Lippincott Williams & Wilkins, 2017) Sertdemir, Merve; Akca, Omer Faruk[Abstract Not Availabe]Öğe The Effectiveness of Methylphenidate in the Treatment of Encopresis Independent from Attention-Deficit Hyperactivity Disorder Symptoms(Korean Neuropsychiatric Assoc, 2015) Akca, Omer Faruk; Yilmaz, SavasSeveral medications are reported to be effective in treatment of encopresis. However, mechanisms of action related to these drugs are not known. We report a patient with ADHD and encopresis whose encopretic signs have disappeared with long acting methylphenidate while they have not changed with atomoxetine.Öğe Effectiveness of Methylphenidate in the Treatment of Encopresis Whether or Not Attention-Deficit/Hyperactivity Disorder Symptoms Are Present(Mary Ann Liebert, Inc, 2013) Yilmaz, Savas; Akca, Omer Faruk[Abstract Not Availabe]Öğe Escitalopram in the Treatment of a 3-Year-Old Child with Posttraumatic Feeding Disorder(Mary Ann Liebert, Inc, 2018) Hosoglu, Esra; Akca, Omer Faruk[Abstract Not Availabe]
