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Öğe Could COVID-19 be a trigger for manic attack in an adolescent?(Springer-Verlag Italia Srl, 2021) Uzun, Necati; Kilic, Ahmet Osman; Akinci, Mehmet Akif; ozgul-Katircioglu, Dilek; Erden, Semih[Abstract Not Availabe]Öğe Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder(Aepress Sro, 2021) Akinci, Mehmet Akif; Uzun, NecatiAIM: This study aims to investigate whether there is a relationship between attention-defi cit/hyperactivity disorder (ADHD) and infl ammation, using hematologic infl ammatory parameters in a large sample of children and adolescents. METHOD: This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts. RESULTS: NLR, PLR, MPV, PDW, WBC and neutrophil counts were signifi cantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were signifi cantly higher in girls than in boys. CONCLUSIONS: The results of this study support the hypothesis that infl ammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confi rm that easily obtainable and reliable hematological parameters can be used when investigating the role of infl ammation in ADHD etiology (Tab. 4, Ref. Text in PDF www.elis.skÖğe Evaluation of subclinical cardiovascular risk in drug-naive pediatric patients with anxiety disorders(Sage Publications Inc, 2024) Akinci, Mehmet Akif; Uzun, Necati; Alp, HayrullahObjective This study aims to evaluate subclinical atherosclerosis in drug-naive children with anxiety disorders using non-invasive measures and to investigate the clinical features associated with subclinical atherosclerosis. Method This study included 37 drug-naive children and adolescents with anxiety disorders and 37 healthy controls. The Children's Depression Inventory (CDI) and the State-Trait Anxiety Inventory (STAI-T and STAI-S) were used to assess children's depression and anxiety levels. Carotid artery intima-media (cIMT), epicardial adipose tissue (EAT), and periaortic adipose tissue (PAT) thicknesses, which are indicators of subclinical atherosclerosis, were obtained by echocardiographic measurements. Results Multivariate analysis of covariance (MANCOVA) revealed a significant main effect for cIMT, EAT thickness, and PAT thickness in both groups, independent of confounding factors such as age, sex, body mass index, mean blood pressure, and family income (Pillai's Trace V = .76, F (1, 72) = 35.60, P < .001, & eta;p(2) = .76). Analysis of covariance (ANCOVA) showed that cIMT, EAT thickness, and PAT thickness values were significantly higher in the anxiety disorder group than in the control group (P < .001). In partial correlation analysis, a positive correlation was observed between STAI-T and cIMT, and EAT thickness. In linear regression analyses, age and STAI-T were identified as correlates of cIMT and EAT thickness levels. Conclusions These results suggest that subclinical cardiovascular risk is significantly increased in children and adolescents with anxiety disorders.Öğe Hemogram parameters in childhood anxiety disorders: Could anxiety disorders be related with inflammation?(Churchill Livingstone, 2021) Uzun, Necati; Akinci, Mehmet AkifIn the etiology of anxiety disorders, immune system and inflammation are suggested to play a role. This study hypothesized that there is a relationship between anxiety disorders and inflammation. This retrospective study included 131 children and adolescents between the ages 6-17 who were diagnosed with anxiety disorders. Control group consisted of 131 healthy children with no history of psychiatric disorders or chronic inflammatory conditions. White blood cell (WBC), neutrophil (NEU), lymphocyte, monocyte, basophil, eosinophil values and other hematological markers were noted. From those values, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and other ratios were calculated. WBC and NEU values were significantly higher in children and adolescents with anxiety disorder compared to the control group. In addition, NLR, MLR and PLR values were significantly higher than the control group. Other measured parameters and calculated values did not differ between study groups. No statistically significant difference was found between Generalized Anxiety Disorder (GAD) group, Social Anxiety Disorder group and Not Otherwise Specified Anxiety Disorders (AD-NOS) group in terms of hematological markers except RDW-CV. Only RDW-CV was found statistically significantly higher in AD-NOS group compared to GAD. These results show that there is an association between inflammation and anxiety disorders. Also, it is postulated that hematological parameters can be used as a useful marker in the follow-up of patients with anxiety disorders.Öğe Methylphenidate-Induced Enuresis: 3 Case Reports(Lippincott Williams & Wilkins, 2021) Uzun, Necati; Akinci, Mehmet Akif; Karatoprak, SerdarAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Methylphenidate (MPH) is one of the most widely used drugs in the treatment of ADHD. Enuresis can occur comorbidly with ADHD. However, enuresis is sometimes seen in patients with ADHD as an adverse effect of MPH treatment. In contrast, in some cases, MPH reportedly improves enuresis in patients with ADHD comorbid with enuresis. The literature is contradictory with regard to the relationship between MPH and enuresis. This report presents the cases of 3 children with ADHD who displayed enuresis during MPH treatment.Öğe Neutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary Study(Korean Coll Neuropsychopharmacology, 2021) Karatoprak, Serdar; Uzun, Necati; Akinci, Mehmet Akif; Donmez, Yunus EmreObjective: Substance use disorder (SUD) is a serious public health problem affecting both the individual and the society, and substance use-related deaths and disability have been shown to increase gradually. Recent etiologic studies have reported that there is a relation between inflammatory parameters and psychiatric disorders. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) used as an indicator of inflammation have been shown to be increased in various psychiatric disorders. In this study, we aimed to investigate the NLR and PLR in adolescents with SUD. Methods: This study was conducted by retrospectively examining the records of 55 male adolescents who were followed up with SUD in a child and adolescent psychiatry outpatient clinic between November 2019-June 2020. Patients who had comorbid psychiatric disorder were included, and those who received any psychotropic medication were excluded. A total of 61 healthy male adolescents in the same age range without any psychiatric disorders were recruited as a control group. Neutrophil-lymphocyte-platelet counts were noted retrospectively from complete blood tests, and NLR-PLR were calculated. Results: The NLR and PLR of adolescents with SUD were significantly higher than the healthy adolescents (p < 0.01, p < 0.01, respectively). In addition, conduct disorder, depression, and attention deficit/hyperactivity disorder, which were determined as the most common comorbid psychiatric disorders had no effects on NLR (p = 0.513, p = 0.584, p = 0.394, respectively) and PLR (p = 0.210, p = 0.346, p = 0.359, respectively). Conclusion: The results of current study indicate that inflammatory processes may have a key role in the pathophysiology of SUD.Öğe Sertraline for Trypophobia: Report of an Adolescent Case(Lippincott Williams & Wilkins, 2020) Akinci, Mehmet Akif; Uzun, NecatiTrypophobia is a clinical entity that is characterized by unpleasant feelings related to or an aversion to irregular patterns of small holes or bumps. There are insufficient data about the etiological factors underlying trypophobia. It has been associated with anxiety disorders because it shows comorbidity and symptom similarity with anxiety disorders. Literature on the treatment strategies of trypophobia is somewhat limited. In this case report, we present an adolescent girl with trypophobia that is successfully treated with sertraline.Öğe Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient(Lippincott Williams & Wilkins, 2020) Uzun, Necati; Akinci, Mehmet AkifBackground Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC. Case Report A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up. Conclusions In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC.
