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    The effects of trans-9 18:1 octadecenoic acid isomer on levels of sICAM-1, sVICAM-1 and IGF-1
    (Walter De Gruyter Gmbh, 2011) Akoz, Mehmet; Kocabas, Rahim; Topcu, Cemile; Gurbilek, Mehmet
    Objective: The effects of trans-9 18: 1 octadecenoic acid isomer from the fatty acid isomers taken with diet on soluble cell adhesion molecules (sICAM-1: Soluble intercellular adhesion molecule-1 and sVCAM-1: Soluble vascular cell adhesion molecule-1) and insulin like growth factor-1 (IGF-1) levels were investigated on rats. Method: The rats which were fed for two weeks by the same diet were separated into experimental and control groups. Fifty mg/day trans-9 18: 1 octadecenoic acid isomer was added to the diet of experimental group for 10 days. Following the completion of special diet, fatty acid composition in both groups was studied by gas chromatography analysis. Results: Trans-9 18: 1 fatty acid level in the experimental group was higher than control group (p<0.01). The soluble cell adhesion molecules (sICAM-1 and sVCAM-1) increased (p<0.01) and IGF-1 levels decreased (p<0.05) in rats fed with trans-9 18: 1 octadecenoic acid. Conclusion: Our results indicate that, high levels of dietary trans fatty acid isomers are a factor in the increasing of cell adhesion molecules (sICAM-1, sVCAM-1) levels and decreasing of IGF-1 levels. Hence, measurement of these parameters may be beneficial in patients with coronary artery disease and atherosclerosis, as well as in other pathological cases. We believe that these parameters may also be useful for early diagnosis.
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    MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels in epidermoid lung cancer
    (Tubitak Scientific & Technological Research Council Turkey, 2013) Oncel, Mufide; Akoz, Mehmet; Oncel, Murat; Kiyici, Aysel; Apiliogullari, Burhan
    Aim: To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls (P = 0.018, 0.041, and 0.034, respectively). Conclusion: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels increased not only in lung tissues, but in the sera of the patients with non-small cell lung cancer. However, further studies are needed to fully evaluate the expression rates and diagnostic efficiency of these parameters in different histopathological subtypes of this cancer and in prospective research with a large number of participants.