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Öğe Clinical and Laboratory Characteristics of COVID-19 Cases Followed in Selcuk University Faculty of Medicine(Doc Design Informatics Co Ltd, 2020) Sumer, Sua; Ural, Onur; Aktug-Demir, Nazlim; Cifci, Seyma; Turkseven, Burcu; Kilincer, Abidin; Turk-Dagi, HaticeObjective: Understanding the natural course of COVID-19 and determining its clinical findings are essential for early diagnosis and treatment. In this study, we aimed to investigate clinical and laboratory characteristics of cases followed with a diagnosis of COVID-19 in Selcuk University Faculty of Medicine Department of Infectious Diseases and Clinical Microbiology. Methods: Among patients followed with a diagnosis of possible/definitive COVID-19, those with a positive SARS-CoV-2 RT-PCR test were evaluated retrospectively in terms of their clinical, laboratory and thorax computed tomography (CT) data. Results: Among 407 patients followed with a diagnosis of possible/definitive COVID-19, 149 (36.6%) were SARS-CoV-2 RT-PCR test-positive. 82 (55%) of the patients were female and 67 (45%) were male. Mean age was 49.3 +/- 7.6 years. 11 (7.4%) were health care workers. While the most common symptom was cough with 46.3%, fever was observed in 29.5%, sore throat in 27.5% and malaise in 26.8% of the patients. 94 (63.1%) of the patients had underlying diseases. Hypertension and diabetes mellitus were the most common underlying disease. Laboratory findings were leukopenia in 12 (8.1%), lymphopenia in 34 (22.8%), thrombocytopenia in 24 (16.1%), elevated D-dimer levels in 43 (28.9%), elevated lactate dehydrogenase levels in 73 (49%), and elevated C-reactive protein (CRP) levels in 45 (30.2%) patients. While 71 (47.6%) of the patients had normal thorax CT, 43 (28.9%) had mild pneumonia, and 35 (23.5%) moderate pneumonia. D-dimer and CRP levels were higher in those with pneumonia than those without pneumonia (p=0.001 and p=0.001, respectively). As the pneumonia level increased, the increase of D-dimer and CRP levels became evident (p=0.003 and p=0.001, respectively). Conclusions: The clinical course of COVID-19 patients varies. It is noteworthy that there is a positive correlation between the severity of pneumonia and the increase in D-dimer and CRP levels in COVID-19.Öğe Diagnostic clues for spondylitis in acute brucellosis(Saudi Med J, 2014) Aktug-Demir, Nazlim; Kolgelier, Servet; Ozcimen, Serap; Sumer, Sua; Demir, Lutfi S.; Inkaya, Ahmet C.Objectives: To determine the diagnostic factors for brucellar spondylitis. Methods: This retrospective study included 227 consecutive brucellosis patients admitted to the Infectious Diseases and Clinical Microbiology clinics of Adiyaman State Hospital and Adiyaman 82nd Year State Hospital, Adiyaman, Turkey between January 2010 and December 2012. Acute brucellosis was diagnosed by standard tube agglutination test, and/or growth of Brucella spp. in appropriately prepared culture media (Bactec). Brucellar spondylitis was diagnosed and followed-up with contrast-enhanced magnetic resonance imaging. Results: Among the 227 brucellosis patients included, 88 (38.8%) were male, and 139 (61.2%) were female. Brucellar spondylitis was detected in 54 patients (23.7%). Brucellar spondylitis patients had higher mean age, higher fever, and higher blood culture positivity rate when compared with brucellosis patients (p=0.001, p=0.001, and p=0.001). Logistical regression analysis determined that male gender (OR: 3.006), older age (OR: 1.025), erythrocyte sedimentation rate (ESR) (OR: 1.067), high fever at the time of admission (OR: 2.550), and positive blood cultures for Brucella spp. (OR: 4.003) values were independently associated with brucellar spondylitis. However, high C-reactive protein (CRP) levels (OR: 0.971) were not found as a risk factor for brucellar spondylitis. Conclusions: The results of this study shows that the risk of developing brucellar spondylitis is high in patients with acute brucellosis, who are at advanced age, who have high fever, that have Brucella spp. growth in their blood culture that has a high ESR value, and who are male.Öğe Evaluation of Depression, Anxiety Level and Quality of Life in Patients With Chronic Hepatitis B and Inactive Hepatitis B Virus Carriers(Aves, 2017) Yigit, Ozge; Ural, Onur; Aktug-Demir, Nazlim; Sumer, Sua; Guler, Ozkan; Demir, Lutfi SaltukObjective: The objective of this study was to compare the anxiety, depression and quality of life scores of chronic hepatitis B (CHB) patients and inactive hepatitis B virus (HBV) carriers with healthy control subjects and to demonstrate the need for a multidisciplinary approach in the follow-up and treatment of patients with HBV infection. Methods: The study was carried out by comparing 200 subjects including 100 CHB patients and 100 inactive HBV carriers, who were admitted to the Outpatient Clinic of Infectious Diseases and Clinical Microbiology Department, Faculty of Medicine, Selcuk University between August 2013 and August 2014 with 100 healthy control subjects. All subjects were given Hospital Anxiety and Depression (HAD) Scale and Short Form-36 (SF-36) to assess their quality of life. Results: Based on the HAD Scale, anxiety risk among the carriers was higher than the control group (p=0.031). Depression risk in the patient (p=0.031) and carrier groups (p=0.046) were higher than the control group. There was no significant difference between the patient and carrier groups with regard to anxiety risk or depression risk (p>0.05). Females had higher anxiety risk in the patient (p=0.015), carrier (p=0.035) and control (p=0.001) groups. Depression risk was also higher in females in the patient (p=0.037) and carrier (p=0.038) groups. There were no significant relations between marital status, family type, place of living and anxiety and depression risks (p>0.05). Three quality of life parameters including general health, role limitations due to physical health and vitality scores in the inactive HBV carriers and CHB patients were lower than those of the control group (p<0.05). Conclusions: Psychological state of the patients who are chronically infected with HBV should not be neglected during treatment and follow-up. If a psychiatric disturbance is identified, effective treatment will increaseÖğe Social Attitude Towards COVID-19 Vaccine 1 Year After the Pandemic(Doc Design Informatics Co Ltd, 2022) Durduran, Yasemin; Aktug-Demir, Nazlim; Demir, Lutfi Saltuk; Kandemir, Bahar; Duman, Ipek; Yucel, MehtapObjective: To increase vaccine awareness, we aimed to determine individuals' knowledge and behavioral approach to the COVID-19 vaccine. Methods: The data of this cross-sectional study were obtained online between June and July 31, 2021. One thousand one hundred seventy-six people over the age of 18 were included in the study. The researchers developed a data collection form consisting of 27 questions. Mean +/- standard deviation and median (1st quarter-3rd quarter) values, numbers, and percentages were used to summarize the data. Chi-square (chi(2)) test was used to show the relationship between categorical variables. Independent predictors of participants' vaccine hesitancy/rejection were analyzed using logistic regression. Statistically, data with p<0.05 were considered significant. Results: A total of 1176 people, 55.7% of whom were women, with a mean age of 39.75 +/- 11.27 years, were included in the study. 71.6% of the participants were married, and 78.9% had a university/postgraduate degree. 9.7% of the participants stated that they were hesitant about the COVID-19 vaccine, and 7.1% refused the COVID-19 vaccine or would not be vaccinated when it was their turn. According to the logistic regression model established to examine the factors that may affect vaccine rejection; Age, the resources used to obtain information about the vaccine, the thought that it would not protect for two years, or the vaccine side effects were high, and the most effective way to get rid of the pandemic was not vaccination, were determined as the factors affecting vaccine rejection. Conclusion: As a result of the research, it was found that the participants had a positive attitude towards the COVID-19 vaccine. It was determined that 9.7% of the study group had vaccine hesitancy, and 7.1% had vaccine rejection.
