Yazar "Akyurek, Nesibe" seçeneğine göre listele
Listeleniyor 1 - 20 / 37
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The 46XX Ovotesticular Disorders of Sexual Development with Dismorphic Features(Elsevier Science Inc, 2015) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe; Yuca, Sevil Ari; Piskin, MesutBackground: Ovotesticular disorders of sexual development (OT-DSD) represent a rare sex development disorder characterized by the presence of both ovarian and testicular tissues in the same or the contralateral gonad. Case: We present the case of a 14-year-old female patient with signs of virilization at a pubertal age and with dysmorphic features, diagnosed as 46, XX OT-DSD. Conclusion: We want to point out that patients with 46 XX OT-DSD may present with virilization at puberty and may be accompanied by dysmorphic features.Öğe Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Children With Turner Syndrome(Springer, 2014) Akyurek, Nesibe; Atabek, Mehmet Emre; Eklioglu, Beray Selver; Alp, HayrullahPatients with Turner syndrome (TS) have an increased risk of cardiovascular morbidity. 29 TS and 25 healthy control subjects (CS) were included in the study. We investigated body mass index, waist circumference, fasting glucose and insulin, homeostatic model assessment (HOMA) index, serum lipids, oral glucose tolerance test, 24-h ambulatory blood pressure (BP) monitoring, and carotid intima-media thickness (CIMT) and compared them with CS. 28 % (N = 7) of TS had insulin resistance (IR), and 36 % (N = 9) had IGT. Mean systolic BP and diastolic BP (DBP) dip were 7.24 +/- A 3.97 % and 11.84 +/- A 6.2 %, respectively. CIMT was greater in TS than in CS (p = 0.00). CIMT was correlated positively with fasting insulin, HOMA index, and insulin-sensitivity check index (r = 0.563, p = 0.015; r = 0.603, p = 0.008; and r = 0.623, p = 0.006, respectively) and negatively with fasting glucose-to-insulin ratio and DBP dipping (r = -0.534, p = 0.022; r = -0.534, p = 0.00, respectively) in the two groups combined. These results provide additional evidence for the presence of subclinical cardiovascular disease and its relation to hypertension in TS. They also indicate a significant relation between DBP dipping and increased arterial stiffness. It is also important to note that our findings show significant relationships between insulin sensitivity and cardiovascular changes and underline the importance of insulin resistance for predicting cardiovascular disease.Öğe Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood(Walter De Gruyter Gmbh, 2014) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe; Piskin, Mehmet M.; Kilinc, Mehmet[Abstract Not Availabe]Öğe Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood(Walter De Gruyter Gmbh, 2014) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe; Piskin, Mehmet M.; Kilinc, Mehmet[Abstract Not Availabe]Öğe Association between vitamin D level and cardiovascular risk in obese children and adolescents(Walter De Gruyter Gmbh, 2014) Atabek, M. E.; Eklioglu, Beray Selver; Akyurek, Nesibe; Alp, HayrullahBackground: The aim of our study was to evaluate the associations between vitamin D deficiency, the atherosclerosis and metabolic syndrome. Methods: Two hundred and forty-seven obese children and adolescents, 8-16 years of age (body mass index>95 p) were included in the study. Anthropometric measurements, blood pressure measurements, lipid profile, vitamin D level and carotid intima media thickness (c-IMT) were measured. MS was diagnosed according to IDF criteria. Results: The prevalance of vitamin D deficieny in obese children and adolescent was 46.6%. Low levels of vitamin D were associated with increased carotis intima media thickness and metabolic syndrome (p=0.03, p=0.04, respectively). For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT. Conclusions: In this study we showed an association between low vitamin D status and atherosclerosis independent of traditional risk factors in obese children and adolescents.Öğe Association between vitamin D level and cardiovascular risk in obese children and adolescents(Walter De Gruyter Gmbh, 2014) Atabek, M. E.; Eklioglu, Beray Selver; Akyurek, Nesibe; Alp, HayrullahBackground: The aim of our study was to evaluate the associations between vitamin D deficiency, the atherosclerosis and metabolic syndrome. Methods: Two hundred and forty-seven obese children and adolescents, 8-16 years of age (body mass index>95 p) were included in the study. Anthropometric measurements, blood pressure measurements, lipid profile, vitamin D level and carotid intima media thickness (c-IMT) were measured. MS was diagnosed according to IDF criteria. Results: The prevalance of vitamin D deficieny in obese children and adolescent was 46.6%. Low levels of vitamin D were associated with increased carotis intima media thickness and metabolic syndrome (p=0.03, p=0.04, respectively). For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT. Conclusions: In this study we showed an association between low vitamin D status and atherosclerosis independent of traditional risk factors in obese children and adolescents.Öğe Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child(Walter De Gruyter Gmbh, 2014) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe[Abstract Not Availabe]Öğe Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child(Walter De Gruyter Gmbh, 2014) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe[Abstract Not Availabe]Öğe Frequency of Vaginal Candida Colonization and Relationship between Metabolic Parameters in Children with Type 1 Diabetes Mellitus(Elsevier Science Inc, 2013) Atabek, Mehmet Emre; Akyurek, Nesibe; Eklioglu, Beray SelverObjectives: Patients with diabetes mellitus (DM) are at risk for vulvovaginal candidasis. The aim of this study was to determine the species-specific prevalence rate and risk of candidiasis in patients with type 1 DM. Methods: Children aged between 8-16 years were included in the study. Clinical and laboratory features of diabetes and evidence of genital symptoms were recorded. Vaginal swabs were taken from patients and placed on Sabouraud's dextrose agar and incubated. Following fasting overnight for 12 hours venous blood samples were taken simultaneously for analyses of blood glucose, HbA1c, and lipid profile. A simple 1-time fiuconazole treatment regimen was used to treat patients with vulvo-vaginal candidiasis. Results: Candida species were isolated in 30 of 76 (39%) swabs of patients with type 1 DM. Subjects who had candida colonization and candidiasis were all acute. The predominant candida species isolated from patients with type 1 DM were C.albicans 50%, C. glabrata 36.6%, C.crusei 3.3%, C.spesies 6.6%, and C.dubliniensis 3.3%. 42 patients had symptoms. The prevalence of candidiasis in symptomatic patients was 59.2%. Subjects with vulvo-vaginal candidiasis had higher mean HbA1c when compared to those who had no such infection (P = .047). Conclusions: There seems to be a significant link between hyperglycemia and vulvo-vaginal candidiasis in patients with type 1 DM. Improving glucose control may reduce the risk of candidiasis and potentially symptomatic infection among children with diabetes. Because of high rate of colonization with candida species in diabetes, patients should undergo periodic screening for genital candidiasis.Öğe Impaired systolic blood dipping and nocturnal hypertension: an independent predictor of carotid intima-media thickness in type 1 diabetic patients(Elsevier Science Inc, 2014) Atabek, Mehmet Emre; Akyurek, Nesibe; Eklioglu, Beray Selver; Alp, HayrullahObjective: Type 1 diabetes in children predicts a broad range of later health problems including an increased risk of cardiovascular morbidity and mortality. This study aimed to evaluate whether nocturnal hypertension and impaired nocturnal dipping affect atherosclerosis in children and adolescents with type 1 diabetes and to investigate the relationship between atherogenic risk factors and carotid intima-media thickness (CIMT). Methods: One hundred fifty-nine type 1 diabetic patients and 100 healthy controls were included in the study. We investigated metabolic and anthropometric parameters such as body mass index (BMI), waist circumference, fasting glucose and insulin, serum lipids, 24 h ambulatory blood pressure monitoring (ABPM), and CIMT and compared these with those in control subjects (CS). Results: No difference was found between type 1 diabetic patients and CS in age, weight, waist/hip ratio, triglyceride, HDL-cholesterol level. However in children with type 1 diabetes, total cholesterol (p = 0.016), and LDL-cholesterol (p = 0.002) levels and CIMT (P < 0.001) were greater than those of controls. It was determined that 10% of type 1 diabetic patients had dyslipidemia. In 23.2% of type 1 diabetic patients, ABPM showed arterial hypertension. CIMT was significantly higher in the hypertensive group than in the nonhypertensive group (P = 0.003). Twenty-three (14.4%) diabetic patients had nocturnal hypertension. CIMT was significantly greater in the nocturnal hypertensive group (p = 0.023). Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dipping was significantly different in diabetic patients (P < 0.001). CIMT was correlated positively with Hba1c (r = 0.220, p = 0.037), and negatively with SBP dipping (r = -0.362, p = 0.020) in the diabetic patients. In stepwise regression analysis, Hba1c and SBP dipping emerged as a significant predictor of CIMT (beta = 0.300, p = 0.044, beta = 0.398 p = 0.009) contributing to 15.58% of its variability. Conclusion: These results provide additional evidence for the presence of subclinical cardiovascular disease (CVD) and its relation to hypertension in type 1 diabetic patients. They also indicate a significant relation between nocturnal hypertension, SBP dipping and increased arterial stiffness. It is also important to note that our findings reveal significant relationships between HBA1c cardiovascular changes and underline the importance of glucose control to predict CVD. (C) 2014 Elsevier Inc. All rights reserved.Öğe Intestinal invagination in diabetic ketoacidosis: case report(Walter De Gruyter Gmbh, 2015) Akyurek, Nesibe; Atabek, Mehmet Emre; Eklioglu, Beray Selver[Abstract Not Availabe]Öğe Intestinal invagination in diabetic ketoacidosis: case report(Walter De Gruyter Gmbh, 2015) Akyurek, Nesibe; Atabek, Mehmet Emre; Eklioglu, Beray Selver[Abstract Not Availabe]Öğe Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?(Walter De Gruyter Gmbh, 2015) Akyurek, Nesibe; Atabek, Mehmet Emre; Eklioglu, Beray Selver; Alp, HayrullahAim: In this study, parameters of metabolic syndrome and dehydroepiandrosterone sulfate (DHEAS) levels in obese children and adolescents were evaluated and the associations between these factors were analyzed. Method: One hundred obese and 40 healthy children/ adolescents were included in the study. Pubertal stages, anthropometric and blood pressure measurements were recorded. Levels of fasting serum lipids, glucose, insulin, and DHEAS, and liver function tests were determined. Carotid intima-media thickness (CIMT) was measured using two-dimensional echocardiography. Steatorrhoeic hepatosis was evaluated using abdominal ultrasonography in the obese group. Results: Mean body weight, body mass index, waist, hip circumference, waist/hip ratio, homeostatic model assessment of insulin resistance, triglycerides, high-density lipoprotein cholesterol, alanine transferase, DHEAS, and CIMT values were significantly higher in the obese group than in the controls. DHEAS levels were found to be positively correlated with waist circumference, waist/hip ratio, and CIMT. Conclusion: Early determination of metabolic and cardiac dysfunction in obese children is important for the prevention of future complications. Since in this study we found a strong association between DHEAS levels and obesity-related metabolic and cardiovascular risk factors, we believe that this may lead to increased interest in further studies of DHEAS in the search for new treatment approaches.Öğe Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?(Walter De Gruyter Gmbh, 2015) Akyurek, Nesibe; Atabek, Mehmet Emre; Eklioglu, Beray Selver; Alp, HayrullahAim: In this study, parameters of metabolic syndrome and dehydroepiandrosterone sulfate (DHEAS) levels in obese children and adolescents were evaluated and the associations between these factors were analyzed. Method: One hundred obese and 40 healthy children/ adolescents were included in the study. Pubertal stages, anthropometric and blood pressure measurements were recorded. Levels of fasting serum lipids, glucose, insulin, and DHEAS, and liver function tests were determined. Carotid intima-media thickness (CIMT) was measured using two-dimensional echocardiography. Steatorrhoeic hepatosis was evaluated using abdominal ultrasonography in the obese group. Results: Mean body weight, body mass index, waist, hip circumference, waist/hip ratio, homeostatic model assessment of insulin resistance, triglycerides, high-density lipoprotein cholesterol, alanine transferase, DHEAS, and CIMT values were significantly higher in the obese group than in the controls. DHEAS levels were found to be positively correlated with waist circumference, waist/hip ratio, and CIMT. Conclusion: Early determination of metabolic and cardiac dysfunction in obese children is important for the prevention of future complications. Since in this study we found a strong association between DHEAS levels and obesity-related metabolic and cardiovascular risk factors, we believe that this may lead to increased interest in further studies of DHEAS in the search for new treatment approaches.Öğe Madelung Deformity Associated with Turner Syndrome: A Case Report(Gazi Univ, Fac Med, 2015) Akyurek, Nesibe; Atabek, Mehtnet Emre; Eklioklu, Beray Selver; Cicek, SalihTurner syndrome (TS) is a chromosomal disorder, which mostly results from a 45 X karyotype and is characterized with short stature, gonadal dysgenesis, renal and cardiac abnormalities. A 6 years 1 month old girl was admitted to our clinic with the complaints of short stature compared to peers. On physical examination, her height was 106.4 cm (SD score-1.74) and weight was 22 kg (SD score-0.5) with breast development and pubic hair consistent with Tanner stage I. She had low nuchal hairline. Remaining systemic physical examination was normal. Laboratory evaluation revealed normal complete blood count, renal, hepatic, and thyroid function test results. Bone age was consistent with 3 years 6 month. Madelung deformity was detected in the left wrist radiography. FSH was 22.5 mIU/mL (N:2.5- 7.04), LH:<0.1 mIU/ mL (N:0.1-12), E2<20 pg/ mL. The result of karyotype analysis was reported to be 45.X0. With this report, it was aimed to emphasize importance of left wrist radiography and in necessary cases determining karyotype analysis for diagnosis of Turner syndrome.Öğe Madelung Deformity Associated with Turner Syndrome: A Case Report(Gazi Univ, Fac Med, 2015) Akyurek, Nesibe; Atabek, Mehtnet Emre; Eklioklu, Beray Selver; Cicek, SalihTurner syndrome (TS) is a chromosomal disorder, which mostly results from a 45 X karyotype and is characterized with short stature, gonadal dysgenesis, renal and cardiac abnormalities. A 6 years 1 month old girl was admitted to our clinic with the complaints of short stature compared to peers. On physical examination, her height was 106.4 cm (SD score-1.74) and weight was 22 kg (SD score-0.5) with breast development and pubic hair consistent with Tanner stage I. She had low nuchal hairline. Remaining systemic physical examination was normal. Laboratory evaluation revealed normal complete blood count, renal, hepatic, and thyroid function test results. Bone age was consistent with 3 years 6 month. Madelung deformity was detected in the left wrist radiography. FSH was 22.5 mIU/mL (N:2.5- 7.04), LH:<0.1 mIU/ mL (N:0.1-12), E2<20 pg/ mL. The result of karyotype analysis was reported to be 45.X0. With this report, it was aimed to emphasize importance of left wrist radiography and in necessary cases determining karyotype analysis for diagnosis of Turner syndrome.Öğe Parathyroid adenoma presented with multiple brown tumors and nephrocalcinosis(Walter De Gruyter & Co, 2013) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe[Abstract Not Availabe]Öğe Parathyroid adenoma presented with multiple brown tumors and nephrocalcinosis(Walter De Gruyter & Co, 2013) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe[Abstract Not Availabe]Öğe Partial Merosin Deficiency and Precocious Puberty(Modestum Ltd, 2015) Eklioglu, Beray Selver; Akyurek, Nesibe; Yuca, Sevil Ari; Atabek, Mehmet EmreThe congenital muscular dystrophies (CMD) are autosomal-recessive disorders. Classical congenital muscular dystrophy is grouped as merosin-positive and merosin-negative (MN-CMD). Precocious puberty in girls has been defined by Marshal and Tanner in 1969. In most of the cases, precocious puberty is idiopathic and is related to premature release of gonadotrophins. So far, the association between merosin deficiency and precocious puberty has not been identified. We report a case of a child with precocious puberty who was diagnosed with merosin deficiency in infancy.Öğe Partial Merosin Deficiency and Precocious Puberty(Modestum Ltd, 2015) Eklioglu, Beray Selver; Akyurek, Nesibe; Yuca, Sevil Ari; Atabek, Mehmet EmreThe congenital muscular dystrophies (CMD) are autosomal-recessive disorders. Classical congenital muscular dystrophy is grouped as merosin-positive and merosin-negative (MN-CMD). Precocious puberty in girls has been defined by Marshal and Tanner in 1969. In most of the cases, precocious puberty is idiopathic and is related to premature release of gonadotrophins. So far, the association between merosin deficiency and precocious puberty has not been identified. We report a case of a child with precocious puberty who was diagnosed with merosin deficiency in infancy.
