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    Biological correlates of major depression and generalized anxiety disorder in women with polycystic ovary syndrome
    (Pergamon-Elsevier Science Ltd, 2013) Annagur, Bilge Burcak; Tazegul, Aybike; Uguz, Faruk; Kerimoglu, Ozlem Secilmis; Tekinarslan, Emine; Celik, Cetin
    Objective: We aimed to compare the levels of serum androgens in women with polycystic ovary syndrome (PCOS) who had a diagnosis of only major depressive disorder (MDD), only generalized anxiety disorder (GAD) or who had no psychiatric disorder, as determined by a structured clinical interview. Another objective of the study was to examine whether an association exists between these psychiatric diagnoses and insulin resistance or body mass index via a comparison among the study groups in terms of these parameters. Method: This study was performed between March 2011 and February 2012. A total of 73 patients were included in the study. The study sample consisted of three groups: PCOS patients with only major depressive disorder (n = 23), PCOS patients with only generalized anxiety disorder (n = 20), and PCOS patients without any diagnosed psychiatric disorders (not diagnosed - ND group, n = 30). Results: Significant difference was found among the three groups with regard to the serum levels of 17-OHP and DHEAS. When multiple comparisons were performed among the groups, 17-OHP levels were significantly higher in the MDD group than in the ND group. DHEAS levels were significantly higher in the MDD group and the GAD group than in the ND group. Conclusion: The present study suggests that MDD and GAD appear to be associated with higher DHEAS levels. (C) 2013 Elsevier Inc. All rights reserved.
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    Birth Weight and Preterm Birth in Babies of Pregnant Women With Major Depression in Relation to Treatment With Antidepressants
    (Lippincott Williams & Wilkins, 2014) Sahingoz, Mine; Yuksel, Goksen; Karsidag, Cagatay; Uguz, Faruk; Sonmez, Erdem Onder; Annagur, Bilge Burcak; Annagur, Ali
    Objective It is unclear whether antidepressant treatment has a preventive effect on negative neonatal outcomes due to major depression in pregnant women. The objective of the present study was to compare women with major depression treated with antidepressants, untreated women with major depression, and healthy women during pregnancy with respect to birth weight and preterm birth. Methods The study sample included a total of 23 women taking antidepressant medication, 36 women who were not taking antidepressant medication for major depression during pregnancy, and 30 healthy women. Major depression was diagnosed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Results The study groups were similar with respect to sociodemographic characteristics. Compared with infants of healthy control subjects, infants of untreated major depressed women had significantly lower birth weight and shorter gestational age at delivery. There is no significant difference between infants of major depressed women treated with antidepressants and infants of healthy subjects for these variables. Conclusions Our results suggest that antidepressants may have beneficial effects on the risk of low birth weight and preterm birth in the infants of depressed women.
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    The effects of maternal major depression, generalized anxiety disorder, and panic disorder on birth weight and gestational age: A comparative study
    (Pergamon-Elsevier Science Ltd, 2013) Uguz, Faruk; Sahingoz, Mine; Sonmez, Erdem Onder; Karsidag, Cagatay; Yuksel, Goksen; Annagur, Bilge Burcak; Annagur, Ali
    Objective: The present study comparatively examined the impact of maternal major depression, generalized anxiety disorder and panic disorder on gestational age and birth weight. Methods: A total of 90 women (24 subjects with major depression, 19 subjects with panic disorder, 22 subjects with generalized anxiety disorder, and 25 healthy subjects) in the perinatal period who were admitted to three hospitals were included in the study. Psychiatric diagnoses were determined by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The birth weight and gestational age of the subjects in each groups were compared with one-way analysis of variance (ANOVA). Results: There were significant differences among the study groups for birth weight and gestational age (P < 0.001 for both variables). These parameters were significantly lower in the subjects with major depression (P = 0.021 and P = 0.015, respectively) and panic disorder (P < 0.001 for both variables) compared to healthy controls. Compared with major depression, panic disorder was associated more negatively with birth weight (P = 0.036). Conclusion: Major depression, and especially panic disorder, may negatively affect the gestational length and birth weight. (C) 2013 Elsevier Inc. All rights reserved.
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    Is Maternal Depressive Symptomatology Effective on Success of Exclusive Breastfeeding During Postpartum 6 Weeks?
    (Mary Ann Liebert, Inc, 2013) Annagur, Ali; Annagur, Bilge Burcak; Sahin, Akkiz; Ors, Rahmi; Kara, Fatih
    Aim: The aim of this prospective study was to examine the relationship between success of exclusive breastfeeding and postpartum depressive symptomatology. Our hypothesis was that mothers with depressive symptoms initially fail exclusive breastfeeding. Subjects and Methods: One hundred ninety-seven mothers were enrolled in the study. The participants were interviewed twice. The first visit was within the first 48 hours after birth. The Edinburgh Postnatal Depression Scale (EPDS) was completed by the participants. The second interview was performed at 6 weeks. Participants answered questions regarding methods of breastfeeding for 6 weeks, any methodological problems, and nipple pain. The EPDS was again completed by the participants at 6 weeks. All newborns were term infants. Results: All the participants were divided into two groups: exclusive breastfeeding and mixed-feeding (partial breastfeeding and/or bottle feeding). Both groups were compared in terms of features, such as mode of delivery, parity, prevalence of depressive symptomatology (at 48 hours and 6 weeks), and delayed onset of lactation within the first 48 hours. Statistical significance was found for only three variables: delayed onset of lactation within the first 48 hours, gestational age, and the problems related to breastfeeding methods. Conclusions: Clinicians should pay special attention to any lactation difficulty during the first week postpartum. Early lactation difficulties are associated with greater risk of early termination of breastfeeding and lower breastfeeding success.
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    Shaken Baby Syndrome Suggestive of The Diagnosis of Osteogenesis Imperfecta in Newborn
    (Modestum Ltd, 2013) Annagur, Ali; Altunhan, Huseyin; Annagur, Bilge Burcak; Ertugrul, Sabahattin; Ors, Rahmi
    Physical child abuse may occur in a broad range of disorders from a mild soft tissue injury to a severe brain damage leading to death. The head trauma resulted from physical abuse is the main reason for the severe and fatal injuries in children, and arises with the clinical triad of externally seen trauma signs, subdural hemorrhage and retinal hemorrhage. In this article, we report a case of shaken baby aged 20-day, who was referred to our clinic with the diagnosis of late neonatal sepsis and osteogenesis imperfecta. A 20-day-old baby was presented to the emergency department of an outer health center with the complaints of restlessness and non-breastfeeding was considered as sepsis, and subsequently when multiple fractures were detected in the radiological investigations, a diagnosis of osteogenesis imperfecta was also considered, and the baby was referred to our hospital. In the examination of the extremities, he had swelling, ecchymose and limited mobility in both arms and the left calf. The extremity radiograms revealed body fractures in both humeri and the left femur. Radiological investigations are very important for the diagnosis of physical abuse, which causes serious mortality and morbidity and is usually difficult to diagnose because of a wrong medical history given by family members or a history taken by the physician carelessly. Discordance between the history given by the family and the radiological findings should be warning for the physician, and the radiological findings must be assessed carefully.