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Öğe Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Arbag, Hamdi; Arslan, Abdullah; Aktan, Meryem; Findik, SidikaIntroduction: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Methods: Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. Results: Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-alpha, interleukin-1 beta, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interteukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. Conclusion: When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Öğe Cervico-Thoracic Giant Lipoma in a Child(2016) Eryılmaz, Mehmet Akif; Yücel, Abitter; Yücel, Hilal; Aricigil, MitatLipomlar vücudun her yerinde görülebilen benign mezenkimal tümörlerdir. Lipomların %25'i baş-boyun bölgesinde görülür ve bunların çoğu posterior servikal üçgende yerleşir. On cm'den daha uzun veya 1000 gramdan daha ağır olan lipomlara dev lipom denir. Servikotorasik lipomlar oldukça nadirdir ve şu ana kadar literatürde dört olgu bildirilmiştir. Bu raporda biz, orta juguler üçgenden başlayıp ön servikal üçgene ve mediastinuma uzanan dev bir lipomun torakotomi yapılmadan başarılı bir şekilde eksizyonunu sunduk.Öğe Computed Tomography Analysis of Nasal Anatomy in Dorsal Preservation Rhinoplasty(Oxford Univ Press Inc, 2022) Eravci, Fakih Cihat; Ozer, Halil; Arbag, Hamdi; Eryilmaz, Mehmet Akif; Aricigil, Mitat; Dundar, Mehmet AkifBackground Subdorsal septal resection and radix osteotomy are distinctive surgical steps in preservation rhinoplasty. Objectives The aim of this study was to evaluate the nasal bone thickness, the level of the septal bony-cartilaginous junction (K area), and the distances of the frontal sinus and skull base from the transverse osteotomy line in the Turkish population by means of conventional computed tomography (CT). Methods A retrospective evaluation was made of 203 consecutive preoperative paranasal CT scans of patients (classified in terms of age and gender) who had undergone rhinoplasty surgery between January 2020 and June 2021. The nasal bone thickness at the medial canthus level, and the distances between the transverse osteotomy line and the K area, the frontal sinus, and the cribriform plate were measured. Results The mean measurements were similar in terms of age groups (P = 0.402, P = 0.542, P = 0.134 and P = 0.276 for ages 18-30, 30-40, 40-50, and >50 years, respectively). The mean nasal bone thickness and the distance between the transverse osteotomy line and the K area showed statistical significance (P = 0.001 and P = 0.001, respectively). In both genders, the mean distances between the transverse osteotomy line and the frontal sinus and the cribriform plate were similar (P = 0.921 and P = 0.280, respectively). The nasal bone was thinner and the K area position more cephalic in females. Conclusions CT plays an important role in preoperative planning. The need for resection of the ethmoid perpendicular bone may be greater in males when lowering the dorsal hump, and hence they may be more prone to skull base complications. It is therefore necessary to be more careful in the surgical stage of subdorsal septal excision in males.Öğe Confirmation of anatomical proximities in endoscopic sinus surgery with computer tomography: A cadaveric study(Bayrakol Medical Publisher, 2023) Erdem, Rukiye Ozcelik; Dundar, Mehmet Akif; Aricigil, Mitat; Arbag, HamdiAim: The aim of this study was to investigate the confirmation of anatomical proximities between endoscopic sinus surgery with computer tomography. Material and Methods: This study was done on 5 fresh frozen cadaver heads between May 2017 to June 2018. High-resolution computed tomography (HRCT) was taken before the operations. Firstly uncinectomy was done. Then all stages of functional endoscopic sinus surgery (FESS), which contains anteriorposterior ethmoidectomy, dissection of the sphenoid sinus and frontal recess, and maxillary sinusotomy were performed from anterior to posterior. Distances between each other landmarks and distances to the nasal vestibule were measured during the surgery. All measurements taken during dissection were measured on the coronal, axial, and sagittal section HRCT. Dissection data were compared with radiological data. Results: As a result of comparing the radiological data and dissection data, there was no significant difference between the data obtained from the sagittal section and the dissection data. A significant difference (P=0.03) was found between the dissection and radiological evaluation in the coronal section except for the measurements of SO-UT (p=0.853) and MP-SA (p=0.972), and in the axial section except for the measurements of the SO-C (p=0.579) and MP-SA (p=1). Discussion: Measurements obtained in the paranasal sinus CT can be used during FESS. While the data obtained in the sagittal section are suitable for the operation plan and can be used directly, the coronal and axial section are not.Öğe Effectiveness of Spreader Graft Versus Autospreader Flap in Reducing Nasal Air Resistance(Lippincott Williams & Wilkins, 2023) Cemiloglu, Muhammed; Aricigil, Mitat; Bayrakci, Erdem; Acar, Guelay; Arbag, HamdiObjective:The authors aimed to compare the functional outcomes of 2 different techniques, spreader graft and autospreader flap, by using them for nasal valve surgery in cadavers using acoustic rhinometry (AR).Method:Ten frozen cadavers who underwent nasal valve surgery between May 2017 and August 2018 were randomly divided into 2 groups. Spreader grafts were applied to 10 nasal valve regions in 1 group, while the autospreader flap method was used on the other 10 nasal valve regions. The effectiveness of the surgical techniques was evaluated utilizing AR.Result:We objectively evaluated the effect of surgery on nasal air resistance by comparing the preoperative and postoperative AR values (MCA1, MCA2, volume) in both the spreader graft and the autospreader flap groups. In addition, the differences in nasal potency gain after the application of both techniques were compared and the superiority of the 2 surgeries in terms of functional gains was evaluated. A statistically significant difference was observed in preoperative and postoperative MCA1, MCA2, and volume values in both the techniques and sides. The authors found more significant nasal valve opening for the spreader graft technique using acoustic rhinometric values when compared with the autospreader flap technique.Conclusions:In both methods, the air resistance was observed to decrease objectively in the nasal valve region. Autospreader flaps increase the nasal valve angle without the need for additional cartilage tissue, and it could be an alternative to spreader grafts.Öğe Isotretinoin's action against cisplatin-induced ototoxicity in rats(Univ Karachi, 2018) Alan, Mehmet Akif; Eryilmaz, Mehmet Akif; Kaymaz, Figen; Suzer, Aysegul; Aricigil, MitatCurrent data do not support the routine use of any agent to prevent cisplatin ototoxicity. Although there are various diseases in which derivatives of vitamin A are used due to their antioxidant effects, there is no study for prevention from ototoxicity. In this study, the protective effect of isotretinoin was investigated on cisplatin ototoxicity in rats. 21 Wistar Albino rats were divided randomly into 3 groups. Group I: cisplatin, Group II: cisplatin + isotretinoin and Group III was the control group. Hearing assessment of all rats was done with ABR and DPOAE tests before and after the procedure. After the procedure, cochleas were resected and transmission electron microscopic examination was performed. Our DPOAE and ABR findings showed that isotretinoin has protective effects on cisplatin ototoxicity. According to transmission electron microscopic findings, isotretinoin has protective effects on cell integrity. We think that new experimental and clinical studies to be carried out in this regard may give us a new option on prevention of cochlea from ototoxicity.Öğe Melatonin prevents possible radiotherapy-induced thyroid injury(Taylor & Francis Ltd, 2017) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Eryilmaz, Mehmet Akif; Aktan, Meryem; Alan, Mehmet Akif; Findik, SidikaPurpose: We aimed to investigate the protective effect of melatonin in radiotherapy-induced thyroid gland injury in an experimental rat model.Materials and methods: Thirty-two rats were divided into four groups: the control group, melatonin treatment group, radiotherapy group and melatonin plus radiotherapy group. The neck region of each rat was defined by simulation and radiated with 2 Gray (Gy) per min with 6-MV photon beams, for a total dose of 18Gy. Melatonin was administered at a dose of 50mg/kg through intraperitoneal injection, 15min prior to radiation exposure. Thirty days after the beginning of the study, rats were decapitated and analyses of blood and thyroid tissue were performed.Results: Tumor necrosis factor- (TNF-), interleukin-1 beta (IL-1), thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05), whereas interleukin-10 (IL-10) and glutathione (GSH) values were higher in the melatonin plus radiotherapy group (p<.05). The infiltration of inflammatory cells and percentage of apoptosis in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05).Conclusions: Melatonin helped protect thyroid gland structure against the undesired cytotoxic effects of radiotherapy in rats.Öğe Minimally Invasive Endoscopic Retrosigmoid Approach to the Cerebellopontine Angle Using a Novel Surgical Instrument: A Cadaveric Study(Aves, 2018) Aricigil, Mitat; Arbag, Hamdi; Dundar, Mehmet Akif; Aziz, Suhayb Kuria; Yilmaz, Mehmet TugrulOBJECTIVES: In this study, we aimed to describe how endoscopes show the neural and vascular structures at the cerebellopontine angle (CPA) through a minimal craniotomy in a well-described anatomic point in the retrosigmoid legion and at the same time, evaluate the endoscopic anatomic exposure and maneuverability. We planned to use the new surgical instrument (endoscope cannula), which we designed on fresh frozen cadavers to simulate a real surgical procedure. MATERIALS and METHODS:The surgical procedure was planned to be performed on 20 sides of 10 fresh cadaver heads. The distance between the aster ion and mastoid process was determined, and the midpoint was then marked. From this midpoint, a craniotomy 2 cm in size was posteriorly made. The endoscope cannula together with 0 degrees or 30 degrees endoscopes was inserted to capture the panoramic views of the neurovascular structures in CPA. Endoscopic anatomic exposure and maneuverability wee evaluated using 0 degrees and 30 degrees endoscopes with/without the endoscope cannula. RESULTS: The surgeon could easily use both hands during the surgical simulation, and maneuverability was seen to increase in CPA with the use of the endoscope cannula. CONCLUSION:The surgeon can work actively with both hands when the endoscopes and the endoscope cannula are used together. We believe that owing to this, the surgeon's maneuverability would increase and a more effective minimally invasive endoscopic retrosigmoid surgery would ensue.Öğe Sudden bilateral hearing loss after organophosphate inhalation(Kare Publ, 2016) Dundar, Mehmet Akif; Derin, Serhan; Aricigil, Mitat; Eryilmaz, Mehmet AkifSudden bilateral hearing loss are seen rarely and the toxic substance exposure constitutes a small part of etiology. A Fifty-eight-year-oldwoman admitted to our clinic with sudden bilateral hearing loss shortly after chlorpyrifos-ethyl exposure. Otolaryngologic examination findings were normal. The patient had 40 dB sensorineural hearing loss (SNHL) on the right ear and 48 dB SNHL on the left ear. Additional diagnostic tests were normal. The conventional treatment for sudden hearing loss was performed. On the second week following organophosphate (OP) exposure the patient's hearing loss almost completely resolved. OP's are heavily used in agriculture and should be taken into consideration as an etiologic factor in sudden hearing loss. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe Update on local allergic rhinitis(Elsevier Ireland Ltd, 2016) Altintoprak, Niyazi; Kar, Murat; Muluk, Nuray Bayar; Oktemer, Tugba; Ipci, Kagan; Birdane, Leman; Aricigil, MitatWe here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
