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Öğe Efficacy of obesity in metastatic colorectal cancer patients treated with bevacizumab-based chemotherapy combinations: A Turkish Oncology Group Study(Oxford Univ Press, 2016) Artac, M.; Korkmaz, L.; Coskun, H.; Dane, F.; Karabulut, B.; Karaagac, M.; Cabuk, D.[Abstract Not Availabe]Öğe First-line anti-EGFR agents (panitumumab or cetuximab) plus chemotherapy in patients with metastatic colorectal cancer: Onco-colon Turkey study subgroup analysis(Elsevier, 2022) Isikdogan, A.; Turk, H.; Bilir, C.; Sendur, M.; Karabulut, B.; Artac, M.; Cicin, I.[Abstract Not Availabe]Öğe The impact of body mass index (BMI) on the progression-free survival of CDK4/6 inhibitors in metastatic breast cancer patients (MBC)(Elsevier, 2022) Artac, M.; Caglayan, D.; Kocak, M. Z.; Geredeli, C.; Tatli, A. M.; Goksu, S. Sezgin; Imaz, M. Karakurt Ery[Abstract Not Availabe]Öğe The prognostic role of XRCC1, ERCC1, ERCC2 and, TP53 single nucleotide polymorphisms (SNPs) in metastatic non-small cell lung cancer (NSCLC)(Elsevier Sci Ltd, 2013) Artac, M.; Geredeli, C.; Yildirim, S.; Inal, A.; Guler, T.; Boruban, C.; Akkuloglu, T.[Abstract Not Availabe]Öğe THE PROGNOSTIC ROLE OF XRCC1, ERCC1, ERCC2, AND TP53 SINGLE NUCLEOTIDE POLYMORPHISMS IN RESECTED NON-SMALL-CELL LUNG CANCER(Elsevier Sci Ltd, 2014) Geredeli, C.; Artac, M.; Yildirim, S.; Dede, I.; Inal, A.; Guler, T.; Boruban, M. C.[Abstract Not Availabe]Öğe A prospectively validated nomogram for predicting the risk of chemotherapy-induced febrile neutropenia: a multicenter study(Springer, 2015) Bozcuk, H.; Yildiz, M.; Artac, M.; Kocer, M.; Kaya, C.; Ulukal, E.; Ay, S.There is clinical need to predict risk of febrile neutropenia before a specific cycle of chemotherapy in cancer patients. Data on 3882 chemotherapy cycles in 1089 consecutive patients with lung, breast, and colon cancer from four teaching hospitals were used to construct a predictive model for febrile neutropenia. A final nomogram derived from the multivariate predictive model was prospectively confirmed in a second cohort of 960 consecutive cases and 1444 cycles. The following factors were used to construct the nomogram: previous history of febrile neutropenia, pre-cycle lymphocyte count, type of cancer, cycle of current chemotherapy, and patient age. The predictive model had a concordance index of 0.95 (95 % confidence interval (CI) = 0.91-0.99) in the derivation cohort and 0.85 (95 % CI = 0.80-0.91) in the external validation cohort. A threshold of 15 % for the risk of febrile neutropenia in the derivation cohort was associated with a sensitivity of 0.76 and specificity of 0.98. These figures were 1.00 and 0.49 in the validation cohort if a risk threshold of 50 % was chosen. This nomogram is helpful in the prediction of febrile neutropenia after chemotherapy in patients with lung, breast, and colon cancer. Usage of this nomogram may help decrease the morbidity and mortality associated with febrile neutropenia and deserves further validation.Öğe Radiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Iceberg(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2015) Ipekci, S. H.; Cakir, M.; Kiyici, A.; Koc, O.; Artac, M.Background: Radiation-induced hypopituitarism is an important late complication of cranial radiotherapy in children and adults. The purpose of this cross-sectional study was to evaluate the effects of radiotherapy on pituitary function in adult nasopharyngeal carcinoma patients. Methods: Pituitary function was evaluated in 30 patients after cranial radiotherapy for nasopharyngeal carcinoma. Somatotroph and corticotroph axes were assessed by insulin tolerance test while gonadotroph and thyroid axes were evaluated by basal pituitary and end organ hormone levels at 10-133 months after radiotherapy. Results: At least one hormonal disorder was observed in 28 (93%) patients after radiotherapy. 26 (87%) patients had one or more anterior pituitary hormone deficiencies. The rates of pituitary hormone deficiencies were 77% for growth hormone, followed by adrenocorticotropic hormone (73%), thyroid-stimulating hormone (27%) and gonadotropins (7%). Hyperprolactinemia was present in 13 (43%) patients. Conclusions: Radiation-induced hypopituitarism is more common than expected in patients with nasopharyngeal carcinoma.Öğe Real-life experience with maintenance chemotherapy plus biologics after the first-line treatment of RAS wild-type metastatic colon cancer (mCRC): A multicenter Onco-Colon Turkey study(Elsevier, 2022) Artac, M.; Cubukcu, E.; Bozkurt, O.; Bilici, A.; Celik, S.; Ozcelik, M.; Oven, B.[Abstract Not Availabe]
