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Öğe Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis(Springer, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Yerlikaya, Fatma Humeyra; Aslan, Uysaler; Hidayetoglu, Bahauddin TahaOxidative stress results from either overproduction of free radicals or insufficiency of several antioxidant defense systems. It leads to oxidation of main cellular macromolecules and a resultant molecular dysfunction. Thyroid hormones regulate oxidative metabolism and, thus, play a role in free radical production. Studies evaluating oxidative stress in patients with hypothyroidism and hyperthyroidism have been encountered in recent years; however, oxidative status in patients with euthyroid autoimmune thyroiditis (AIT) was not investigated previously. Thirty-five subjects with euthyroid AIT and 35 healthy controls were enrolled in the study. Serum oxidative status was determined by the measurement of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidized-low density lipoprotein (ox-LDL) levels. Serum TAS levels were significantly lower (p < 0.001), while serum TOS levels and IMA levels were significantly higher (p < 0.001 and p = 0.020, respectively) in patients compared to controls. In both groups, ox-LDL levels were similar (p = 0.608). Serum TAS levels were negatively correlated with antithyroid peroxidase and anti-thyroglobulin (anti-TG) levels (rho = -0.415, p = 0.001 and rho = -0.484, p < 0.001, respectively). Serum TOS was positively correlated with anti-TG levels (rho = 0.547, p < 0.001). Further, TAS was positively correlated with free T4 levels (r = 0.279, p = 0.043). No correlation was observed between thyrotropin, free T3 levels, and TOS and TAS levels. These results suggest that oxidants are increased, and anti-oxidants are decreased in patients with euthyroid AIT, and oxidative/anti-oxidative balance is shifted to the oxidative side. Increased oxidative stress might have a role in thyroid autoimmunity.Öğe Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?(Verlag Hans Huber, 2019) Can, Ummugulsum; Uysal, Saliha; Ugur, Ayse Ruveyda; Toker, Aysun; Aslan, Uysaler; Hidayetoglu, Bahauddin TahaVitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Our study group includes 45 subjects with vitamin D deficiency (Group 1) (20 M, 25 F; mean age 37.72 +/- 7.70 years) and 40 age and sex-matched healthy subjects with normal serum levels of vitamin D (Group 2) (19 M, 21 F; mean age 39.26 +/- 7.41 years). Plasma 25 (OH) vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Plasma YKL-40 analysis was performed by ELISA. Serum hs-CRP levels were measured by nephelometric method. Plasma vitamin D levels below 20 ng/mL were accepted as vitamin D deficiency. Although we could not find any significant differences by means of serum hs-CRP levels between Group 1 and Group 2 (2.21 (0.27-11.70); 1.79 (0.16-9.85) mg/L, p = 0.247), plasma YKL-40 levels were significantly higher in group 1 than group2 (70.47 (17.84-198.50); 47.14 (4.80-135.48) ng/mL, p = 0.047). In literature, vitamin D deficiency is associated with inflammation. In our study, we found similar hs-CRP levels between groups and higher YKL-40 levels in group 1. Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.Öğe Mide ve kolorektal kanser vakalarında tümör markırlarından CEA, CA 19-9, AFP ve CEA 125'in klinik kullanımının ve aralarındaki ilişkinin değerlendirilmesi(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 1996) Aslan, Uysaler; Ecirli, ŞamilTümör markırlarından CEA, CA 19-9, CA 125 ve AFP'nin mide ve kolorektal kanserlerde klinik kullanımlarını ve sensitivite-spesifisite değerlerini karşılaştırmayı amaçladığımız çalışmaya 46 mide kanserli, 34 kolorektal kanserli, 30 benign gastrointestinal sistem hastalıklı ve 28 sağlıklı yetişkin olmak üzere 138 vaka alındı. Mide kanserli hastalarda CA 19-9, kolorektal kanserli hastalarda da CEA seviyesi benign hastalıklı ve kontrol gruplarına göre anlamlı derecede yüksekti (p < 0,01). Tümör marker seviyeleri yönünden mide kanserli grup ile kolorektal kanserli grup arasında ve benign hastalıklı grup ile kontrol grubu arasında anlamlı fark yoktu (p > 0.05). Metastazlı mide ve kolorektal kanser vakalarında tüm tümör marker seviyeleri erken evrelere göre anlamlı derecede yüksekti (p < 0.05). Tümör markalarının mide ve kolorektal kanserlerde sensitivite ve spesifisite değerleri hesaplanarak ayrı ayrı ve kombine olarak değerlendirildi. Sınır değeri 10 ng/ml iken CEA'mn sensitivitesi ve spesifisitesi mide kanserinde %37-%100, kolorektal kanserlerde %50-%100 bulundu. %100 spesifısitede CA 19-9'un (sınır değeri 33 U/ml ) sensitivitesi mide kanserinde CEA' dan yüksek iken (%39), kolorektal kanserlerde CEA'dan düşük (%35) idi. Sınır değerleri düşürüldüğünde CEA'nun sensitivitesi, CA 19-9'un ise spesifisitesi birbirlerinden yüksek bulundu. Kombine ölçümlerde ise sensitivitenin yükseldiği, spesifısitenin de düştüğü görüldü. Ayrıca asitli ve CEA ile CA 19-9'un menfi olduğu bazı vakalarda CA 125'in faydalı olabileceği tesbit edildi. Sonuç olarak, mide ve koloraktal kanserlerin teşhis, preoperatif değerlendirme ve takip gibi klinik uygulamalarında CEA ve CA 19-9 gibi tümör markırlarından istifâde edilebilir.Öğe Non-Caseating Granulamatus Nephritis: Rare Sign of Sarcoidosis(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2016) Gencer, Vedat; Guney, Ibrahim; Yazici, Raziye; Esen, Hasan; Aslan, Uysaler; Bolukbas, OzdenSarcoidosis is chronic multisystem granulomatous disease. It can rarely cause renal structural and functional damage. Renal impairment is mostly due to the calcium metabolism and associated with hypercalciuria, nephrolithiasis and nephrocalcinosis. Non-caseating granulomatous nephritis can also be seen in few patients. We diagnosed non-caseating granulomatous nephritis with renal biopsy in a 50-year-old female pulmonary sarcoidosis case. Steroid treatment was immediately started and there was a significant decrease in proteinuria and creatinine after a month. Proteinuria and serum creatinine increase are important in patients with sarcoidosis and treatment must be started immediately to prevent end-stage renal failure.Öğe Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency(Sbem-Soc Brasil Endocrinologia & Metabologia, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Hidayetoglu, Bahauddin Taha; Aslan, Uysaler; Buyuktorun, Ilker; Yerlikaya, Fatma HumeyraObjective: Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D. Materials and methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D. Results: Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels. Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.Öğe Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency(Sbem-Soc Brasil Endocrinologia & Metabologia, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Hidayetoglu, Bahauddin Taha; Aslan, Uysaler; Buyuktorun, Ilker; Yerlikaya, Fatma HumeyraObjective: Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D. Materials and methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D. Results: Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels. Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.
