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    Association between vitamin D level and cardiovascular risk in obese children and adolescents
    (Walter De Gruyter Gmbh, 2014) Atabek, M. E.; Eklioglu, Beray Selver; Akyurek, Nesibe; Alp, Hayrullah
    Background: The aim of our study was to evaluate the associations between vitamin D deficiency, the atherosclerosis and metabolic syndrome. Methods: Two hundred and forty-seven obese children and adolescents, 8-16 years of age (body mass index>95 p) were included in the study. Anthropometric measurements, blood pressure measurements, lipid profile, vitamin D level and carotid intima media thickness (c-IMT) were measured. MS was diagnosed according to IDF criteria. Results: The prevalance of vitamin D deficieny in obese children and adolescent was 46.6%. Low levels of vitamin D were associated with increased carotis intima media thickness and metabolic syndrome (p=0.03, p=0.04, respectively). For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT. Conclusions: In this study we showed an association between low vitamin D status and atherosclerosis independent of traditional risk factors in obese children and adolescents.
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    Association between vitamin D level and cardiovascular risk in obese children and adolescents
    (Walter De Gruyter Gmbh, 2014) Atabek, M. E.; Eklioglu, Beray Selver; Akyurek, Nesibe; Alp, Hayrullah
    Background: The aim of our study was to evaluate the associations between vitamin D deficiency, the atherosclerosis and metabolic syndrome. Methods: Two hundred and forty-seven obese children and adolescents, 8-16 years of age (body mass index>95 p) were included in the study. Anthropometric measurements, blood pressure measurements, lipid profile, vitamin D level and carotid intima media thickness (c-IMT) were measured. MS was diagnosed according to IDF criteria. Results: The prevalance of vitamin D deficieny in obese children and adolescent was 46.6%. Low levels of vitamin D were associated with increased carotis intima media thickness and metabolic syndrome (p=0.03, p=0.04, respectively). For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT. Conclusions: In this study we showed an association between low vitamin D status and atherosclerosis independent of traditional risk factors in obese children and adolescents.
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    A case of vitamin D dependent rickets type 1a with a novel mutation in the Turkish population
    (Nature Publishing Group, 2018) Tasdemir, P.; Eklioglu, B. S.; Atabek, M. E.
    [Abstract Not Availabe]
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    A case with Kleefstra Syndrome derived from ring chromosome 9
    (Nature Publishing Group, 2019) Eklioglu, B. S.; Tasdemir, P.; Simsek, L.; Atabek, M. E.
    [Abstract Not Availabe]
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    Evaluation of the relationship between cardiovascular risk factors and periaortic fat thickness in children with type 1 diabetes mellitus
    (Masson Editeur, 2015) Akyurek, N.; Atabek, M. E.; Eklioglu, B. S.; Alp, H.
    [Abstract Not Availabe]
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    INFLUENCE OF GLYCEMIC CONTROL AND BODY COMPOSITION ON IRISIN LEVELS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
    (Editura Acad Romane, 2022) Beray, S. E.; Atabek, M. E.; Kucukkagnici, Y.; Kurban, S.; Selver, M. B.; Iyisoy, M. S.
    Aim. We investigated the relationship between irisin concentrations and glycemic control, body composition and anthropometric measures in children with type 1 diabetes mellitus. Methods. The study involved 40 subjects with T1DM prospectively. Glycemic control was evaluated. Body composition was analyzed with a bioimpedance analyzer (BIA). Serum irisin concentrations were measured using an ELISA kit. Results. Irisin levels were found higher in BMI <17 kg/m(2) group (p=0.002) compared to BMI >17 kg/m(2). Irisin level was negatively correlated with weight, height, BMI, fat free mass, skeletelal muscle mass, basal metabolic rate (r= -0.40, p= 0.011; r=-0.32, p=0.046; r=-0.366, p= 0.022; r=-0.423, p= 0.007; r=-0.430, p=0.006; r=-0.416, p=0.009, respectively); there was a strong correlation between LDL-C and irisin levels (r=0.367, p=0.02). In multivariate linear regression analyses model, irisin concentrations were correlated with weight (beta-coefficient= - 0.391, p= 0.015). LDL-C is associated, but not correlated significantly with irisin levels, (beta-coefficient =0.272, p=0.084). Conclusion. As a result, weight and LDL-C were the predictors of circulating irisin. To our knowledge, this study is the first examining association between irisin levels and body composition comprehensively, in children with type 1 diabetes mellitus.
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