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Öğe Curcumin improves spatial memory and decreases oxidative damage in aged female rats(Springer, 2013) Belviranli, Muaz; Okudan, Nilsel; Atalik, Kismet Esra Nurullahoglu; Oz, MehmetAging induced cognitive impairment has been well documented for many years and several antioxidant strategies have been developed against this impairment. Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties. We hypothesized that curcumin would have an influence on cognitive functions in aged female rats. The purpose of the present study was to investigate the effects of curcumin supplementation on cognitive impairment evaluated by Morris water maze (MWM) as well as the oxidative stress induced by aging in female rats. Rats were randomly divided into either control or curcumin-supplemented groups. Curcumin or vehicle (corn oil) were given once daily for a period of 12 days, beginning 7 days prior to and 5 days during the behavioral tests. Behavioral assessment was performed in MWM. At the end of the behavioral test, blood samples and brain tissues were taken for the analysis of malondialdeyde (MDA), protein carbonyl and glutathione levels. During the training session, curcumin supplementation decreased latency to reach to the platform and the total distance traveled. During the probe trial, curcumin supplementation increased the number of platform crossings. In addition to the behavioral testing, biochemical results showed that MDA levels decreased in brain tissue by curcumin supplementation. It may be concluded that, curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.Öğe THE EFFECT OF ENVIRONMENTAL ENRICHMENT AND WESTERN DIET ON THE TRACE ELEMENT STATUS AND OXIDATIVE STRESS IN RATS(Nobel Ilac, 2020) Can, Ummugulsum; Yerlikaya, Fatma Humeyra; Oz, Mehmet; Atalik, Kismet Esra Nurullahoglu; Gergerlioglu, Hasan SerdarObjective:The Western diet (WD), which is rich in highfat diet (HFD) and high-sucrose diet (HSD), is related to oxidative stress. Enriched environment (EE) with social interaction, physical exercise and continuous learning tasks has been shown to reduce oxidative stress, the inflammatory response, and increase the anti-oxidative defense. Therefore, the present study has aimed to clarify the effects of the EE and WD-fed rats on marker malondialdehyde (MDA) and trace element (TE) levels (iron [Fe], copper [Cu], zinc [Zn], chromium [Cr], selenium [Se], magnesium [Mg] and molybdenum [Mo]). Material and Method: Male Wistar albino rats were housed in either an enrichment (n=24) or standard environment (n=24) and fed with HFD (35% of energy as fat) (n=8), HSD (100% of carbohydrate as sucrose) (n=8), or standard rat chow(n=8), for 4 weeks. Inductively-coupled plasma mass spectrometry was used for determination of the serum TE levels. Results: The serum levels of MDA (p<0.05), Fe, Cu, Mo and Mg increased, while the serum levels of Cr and Se decreased, and additionally, the serum levels of Zn did not changed in the HFD and HSD groups. EE decreased partially the serum levels of MDA, Fe, Mo, and did not affect the serum levels of Cu, while it increased the serum levels of Mg, Cr, Se and Zn; however, there was no significant difference between all of the experimental groups (all; p>0.05). Conclusions: Our study demonstrated that HFD and HSD led to oxidative stress and adversely affected the serum level of TE in rats, and that the EE reversed partially this status.Öğe Effects of Cisplatin and Curcumin on the Hypothalamic-Pituitary-Adrenal Axis(Wiley-Blackwell, 2015) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Atalik, Kismet Esra Nurullahoglu; Yerlikaya, Fatma Humeyra[Abstract Not Availabe]Öğe Effects of the Environmental Enrichment on Learning and Memory in High-Fat Diet-Fed Rats(Wiley-Blackwell, 2015) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Atalik, Kismet Esra Nurullahoglu; Yerlikaya, Fatma Humeyra[Abstract Not Availabe]Öğe Interaction of Nitrergic and Cholinergic Systems on Anxiety and Depression-Like Behaviors in Diabetic Rats with Streptozotocin(Wiley, 2023) Oz, Mehmet; Aslanlar, Durmus Ali; Atalik, Kismet Esra Nurullahoglu[Abstract Not Availabe]