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    A case-control study on the temperament and Psychological mood of patients with chronic Hepatitis B
    (Modestum Ltd, 2017) Findikli, Ebru; Ates, Selma; Kandemir, Bahar; Karaaslan, Mehmet Fatih; Camkurt, Mehmet Akif; Izci, Filiz; Durduran, Yasemin
    Objective: To evaluate the personality and temperament traits in patients with chronic hepatitis B in comparison to healthy subjects and to determine whether there is a relation between personality trait and level of anxiety or depression. Materials/Subjects and Method: This was a case-control study in which 67 patients who had been under follow-up with diagnosis of chronic hepatitis B and 103 aged-matched healthy subjects were included. Study participants were asked to complete three self-report questionnaires-Temperament and Character Inventory (TCI) to define personality traits, Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) to evaluate presence and severity of depression and anxiety. Results: Total and sub-scale scores of five out of seven dimensions of TCI-reward dependence, persistence, self-directedness, cooperativeness, and self-transcencewere significantly higher in Group 1 than Group 2. Total BDI and BAI scores were significantly higher in Group 1 than Group 2. Significantly more patients had a BDI score of 17 or over in Group 1 than Group 2. There was no significant correlation between total scores of TCI dimensions and total BAI or BDI scores except weak correlations between harm avoidance or self-directedness and total BAI or BDI scores. Conclusion: In terms of personality trait, patients with chronic hepatitis B exhibit higher reward dependence, persistence, self-directedness, cooperativeness, and self-transcendence from healthy population. The personality traits of patients should be considered during the management of hepatitis B in order to optimize treatment outcome and to prevent development of new mental health problems during the course of the disease.
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    GPER-1 in chronic hepatitis B
    (Elsevier, 2020) Kandemir, Bahar; Ates, Selma; Kurutas, Ergul Belge; Durduran, Yasemin; Erayman, Ibrahim; Bitirgen, Mehmet
    Estrogen has a significant role in regulating cell proliferation, growth, migration, aging, and many disease states. Estrogen shows its effects through estrogen receptors alpha, beta, and G protein-coupled estrogen receptor 1 (GPER1). The aim of this study is to evaluate serum GPER1 levels and its relationship with fibrosis score in chronic hepatitis B patients. The cases were selected from two university hospitals and consisted of patients who had not previously been treated for hepatitis B, were over 18. Quantitative sandwich enzyme immunoassay technique was used for measuring the serum levels of GPER1. The data evaluated were analyzed by using the statistical tests. Out of the 65 cases; 26 (40%) had hepatitis B, 39 (60%) were controls. Patients underwent liver biopsy. GPER1 levels were significantly high in Hepatitis B group (p < 0.001). Out of the 26 hepatitis B patients; 21(80,8%) had low-stage fibrosis, 5(19,2%) had high-stage fibrosis. When the GPER1 level was >= 017600000 the sensitivity, specificity, positive predictive value, and negative predictive value for the hepatitis B patients were found to be 96%, 87,7%, 96%, and 92,8%, respectively. GPER levels have shown high expression in patients with chronic hepatitis B.