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    The effects of selenium and vitamin E on lung tissue in rats with sepsis
    (Canadian Soc Clinical Investigation, 2012) Atli, Mustafa; Erikoglu, Mehmet; Kaynak, Adnan; Esen, Haci H.; Kurban, Sevil
    Purpose: In this study we examined the ability of selenium and vitamin E to prevent sepsis-induced changes in lung tissue. Methods: Fifty rats were divided into five groups: Group 1: Control group; Group 2: Sepsis group. In this group only cecal ligation and perforation (CLP) was performed. Group 3: Selenium group. An intraperitoneal dose of 100 mu g selenium was given for the first two days followed by a daily dose of 40 mu g for the next five days. CLP was performed the following day. Group 4: Selenium and vitamin E group. In addition to selenium, vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day. Group 5: Vitamin E group. Vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day. Results: There were significant differences between Group 2 and all other groups in terms of blood gas values (pH, pCO2, SaO2), and leukocyte, C-reactive protein (CRP) and glutathione peroxidase levels (p< 0.005). There was no statistically significant difference between groups 3, 4 and 5 in terms of histopathological changes in lung tissue (p> 0.05), but all groups were significantly different compared with Group 2 (p< 0.05). Conclusion: Sepsis-induced lung tissue damage can be reduced or prevented by pretreatment with of selenium and/or vitamin E in a rat model.