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    Diagnostic Value of Adropin Levels in Acute Pulmonary Embolism Patients
    (Galenos Publ House, 2020) Ayranci, Mustafa Kursat; Gul, Mehmet; Sonmez, Leyla Ozturk; Aydemir, Fatma Humeyra Yerlikaya; Medni, Mohamed Refik
    Aim: This study aimed to evaluate the relationship between serum adropin levels in patients with acute pulmonary embolism (PE). Materials and Methods: Patients pre-diagnosed with PE based on computed tomographic pulmonary angiography findings and not fulfilling any of the exclusion criteria were included in the PE group. An identical number of participants with comorbidities similar to those of the PE group were included in the control group. These patientswere selected from those who had been referred to the emergency department and were not considered to have PE based on clinical symptoms and risk scores. Results: Serum adropin levels were found to be high in the PE group. Although the adropin values were high in the case of all comorbidities, the values significantly elevated only in patients with hypertension, acute ischaemic stroke, and previous history of PE. The adropin values were quite different among the Wells score categories, and the mean adropin levels varied significantly between the PE and control groups. Conclusion: In this study, the plasma adropin levels were significantly high in patients with acute PE and exhibited high positive predictivity, sensitivity, and specificity in detecting PE.
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    Sclerostin and TNF-related weak inducer of apoptosis: can they be important in the patients with glomerulonephritis?
    (Assoc Medica Brasileira, 2023) Ozer, Hakan; Baloglu, Ismail; Aykut, Talat; Demirci, Mehmet Ali; Aydemir, Fatma Humeyra Yerlikaya; Turkmen, Kultigin
    OBJECTIVE: Sclerostin is a protein produced by osteocytes, kidneys, and vascular cells and has many effects on kidney and vascular structures. Soluble TNF-related weak inducer of apoptosis is a proinflammatory cytokine that may cause glomerular and tubular injury and increase sclerostin expression. This study aimed to investigate serum sclerostin and soluble TNF-related weak inducer of apoptosis levels in patients with glomerulonephritis and the effects they may be associated with.METHODS: This cross-sectional study included 93 patients, 63 of whom were glomerulonephritis and 30 were healthy controls. Serum sclerostin, soluble TNF-related weak inducer of apoptosis, and 24-h urinary protein excretion were measured, and pulse wave velocity was calculated for arterial stiffness.RESULTS: Serum sclerostin and soluble TNF-related weak inducer of apoptosis were higher in glomerulonephritis patients than in the control group, and serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were correlated with both proteinuria and pulse wave velocity. In addition, in the regression analysis, serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were found to be independent predictors of proteinuria in patients with glomerulonephritis.CONCLUSION: This is the first study to show that serum sclerostin and soluble TNF-related weak inducer of apoptosis are elevated in glomerulonephritis patients, and these two markers correlate with arterial stiffness and proteinuria in these patients. Considering the effects of sclerostin and soluble TNFrelated weak inducer of apoptosis in patients with glomerulonephritis, we think these mechanisms will be the target of both diagnosis and new therapies.
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    Sclerostin and TNF-related weak inducer of apoptosis: can they be important in the patients with glomerulonephritis?
    (Assoc Medica Brasileira, 2023) Ozer, Hakan; Baloglu, Ismail; Aykut, Talat; Demirci, Mehmet Ali; Aydemir, Fatma Humeyra Yerlikaya; Turkmen, Kultigin
    OBJECTIVE: Sclerostin is a protein produced by osteocytes, kidneys, and vascular cells and has many effects on kidney and vascular structures. Soluble TNF-related weak inducer of apoptosis is a proinflammatory cytokine that may cause glomerular and tubular injury and increase sclerostin expression. This study aimed to investigate serum sclerostin and soluble TNF-related weak inducer of apoptosis levels in patients with glomerulonephritis and the effects they may be associated with.METHODS: This cross-sectional study included 93 patients, 63 of whom were glomerulonephritis and 30 were healthy controls. Serum sclerostin, soluble TNF-related weak inducer of apoptosis, and 24-h urinary protein excretion were measured, and pulse wave velocity was calculated for arterial stiffness.RESULTS: Serum sclerostin and soluble TNF-related weak inducer of apoptosis were higher in glomerulonephritis patients than in the control group, and serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were correlated with both proteinuria and pulse wave velocity. In addition, in the regression analysis, serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were found to be independent predictors of proteinuria in patients with glomerulonephritis.CONCLUSION: This is the first study to show that serum sclerostin and soluble TNF-related weak inducer of apoptosis are elevated in glomerulonephritis patients, and these two markers correlate with arterial stiffness and proteinuria in these patients. Considering the effects of sclerostin and soluble TNFrelated weak inducer of apoptosis in patients with glomerulonephritis, we think these mechanisms will be the target of both diagnosis and new therapies.