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    Left ventricular myocardial deformation abnormalities in seizure-free children with epilepsy
    (W B Saunders Co Ltd, 2018) Celik, Serkan Fazli; Baratali, Emre; Guven, Ahmet Sami; Torun, Yasemin Altuner
    Purpose: Although there is a higher risk of structural cardiac disease in people with epilepsy, there is no detailed advanced analysis of cardiac functions in patients with epilepsy. This study aimed to determine early echo cardiographic findings of Left Ventricular (LV) dysfunction using cardiac strain technique in seizure-free children with epilepsy. Method: The study investigated 60 children with epilepsy who had no seizures in the preceding 6 months, without any known cardiovascular disease and treated with one antiepileptic drug and 60 healthy subjects who underwent clinical evaluation including electrocardiography (ECG), standard echocardiography, tissue Doppler imaging (TDI) and two-dimensional Speckle Tracking Echocardiography (2DSTE). Results: Despite the normal M-mode values, global longitudinal strain of the epilepsy of the control group was as follows: -16.86 +/- 3.71,-18.95 +/- 3.75, respectively (p = 0.001); global strain rates were determined as follows: -0.99 +/- 0.23,-1.14 +/- 0.31, respectively (p = 0003). The patients also had increased A-wave velocity, and decreased E/A ratio (p < 0.01). TDI results showed diastolic dysfunction as mirrored by significantly increased isovolemic relaxation time (IVRT), Early mitral inflow (E)/ Early diastolic velocity (E'), and Tei index (p < 0.01). There was no significant difference in LV torsion, Peak LV twist, and ECG parameters between the patients and the controls. Conclusions: In seizure-free patients, cardiac systolic and diastolic functions were impaired when compared to healthy children. There was no difference in the patient group to explain the decline in cardiac functions and there may be unknown different factors besides the known risk factors.