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    Are dietary and serum advanced glycation end-products related to inflammation and oxidation biomarkers in breast cancer patients: a follow-up study
    (Springer, 2023) Alkan, Senay Burcin; Artac, Mehmet; Aksoy, Faruk; Belviranli, Mehmet Metin; Gurbilek, Mehmet; Cizmecioglu, Hilal Akay; Rakicioglu, Neslisah
    PurposeThis study is aimed at evaluating the relationship between dietary and serum advanced glycation end-products (AGEs) with serum inflammatory and oxidative stress biomarkers in breast cancer (BC).MethodsA sample of BC patients was followed for 12 months (March 2020-January 2022). Three-day food consumption record and serum samples were taken before surgery (T1), before chemotherapy (T2), at the 6(th) month of chemotherapy (T3), and at the 12(th) month of chemotherapy (T4). Dietary AGE intake was represented by carboxymethyl lysine (dCML). Serum levels of CML, inflammation, and oxidation biomarkers were determined with biochemical blood tests. The results were compared according to human epidermal growth factor receptor-2 (HER2) status.ResultsThirty-two women with BC and 32 age and body mass index-matched healthy women participated. No significant correlation was found between dCML and serum CML, inflammatory or oxidative stress biomarkers at T1, T2, and T4. A weak positive correlation was demonstrated between dCML and serum malondialdehyde levels (rho=0.355, p=0.046) at T3. The serum CML, inflammation, and oxidation biomarker levels of the HER2- group were significantly higher than those of the HER2+ group at T1.ConclusionThis study suggests that there is limited correlation between dCML and serum inflammation and oxidative stress biomarkers in BC patients. Inflammation and oxidative biomarker levels appear to decline with treatment although dietary and serum AGE levels show not a corresponding significant decline. The HER2- subtype appears to be associated with higher dietary and serum AGEs and higher inflammatory and oxidative stress biomarkers.
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    Comparison of two different techniques in emergency surgery of colon diverticulitis: Hartmann's procedure and resection with primary anastomosis
    (Wiley, 2022) Senturk, Mustafa; Celik, Abdulkadir; cakir, Murat; Yildirim, Mehmet Aykut; Belviranli, Mehmet Metin
    Colon diverticula may require emergency or elective surgery depending on its complications. Our aim is to compare the Hartmann's procedure and resection with primary anastomosis in the patients with colon diverticulitis and to demonstrate the surgical approach of our clinic. Patients were evaluated retrospectively who were operated for colon diverticulitis between January 2010 and January 2020. The patients who underwent emergency surgery for left colon diverticulitis were divided into two groups as patients with primary anastomosis resection (group 1) and Hartmann's procedure (group 2) and the groups were compared. In the aspect of the development of complications there was no remarkable difference between the groups (P = .56). Postoperative early mortality rate was similar in two groups (P = .12). According to the Hinchey classification, 31.7% of the cases were stage I, 9.8% were stage II, 31.7% were stage III, and 26.8% were stage IV. There was not a distinction in morbidity and mortality rates between Hartmann's procedure and resection with primary anastomosis. The best surgical approach should be determined by considering the operation to be performed, the patient's preferences, clinical status, and the predicted results of the surgical treatment of perforated diverticulitis.
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    The Evaluation of Dietary Antioxidant Capacity, Dietary Inflammatory Index and Serum Biomarkers in Breast Cancer: A Prospective Study
    (Routledge Journals, Taylor & Francis Ltd, 2023) Alkan, Senay Burcin; Artac, Mehmet; Aksoy, Faruk; Belviranli, Mehmet Metin; Gurbilek, Mehmet; Cizmecioglu, Hilal Akay; Rakicioglu, Neslisah
    Dietary antioxidant capacity (dTAC) and dietary inflammatory index (DII) are commonly used to assess nutrition. This prospective study examined dTAC, DII, and serum biomarkers in women with breast cancer (BC). Patients were followed-up before surgery (T-1), before chemotherapy (T-2), at 6(th) (T-3) and 12(th) months of chemotherapy (T-4). Serum tumor necrosis factor alpha, interleukin 1 & beta;, interleukin 6, protein carbonyl, malondialdehyde, total antioxidant capacity (TAC), and total oxidant status levels were analyzed. Dietary antioxidant intake, dTAC, and DII were determined using a three-day dietary record. dTAC was calculated using vitamin C equivalent (VCE), oxygen radical absorption capacity (ORAC), trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP), and ferrous ion reducing antioxidant potential (FRAP). This study included 32 women with BC and 32 controls (CG). ORAC, TEAC, TRAP, and FRAP were significantly lower in BC than in CG. During follow-up, only ORAC increased significantly at T-2 compared to T-1. A weak positive correlation was found between dTAC (VCE) and serum TAC levels at T-2 (rho = 0.371, p = 0.036). The relationship between diet and serum biomarkers was not significant. Multicenter prospective studies on different age groups are needed to understand the association between diet and serum biomarkers levels in patients with BC.