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Öğe Early severe anemia as the first sign of cystic fibrosis(Springer, 2016) Sismanlar, Tugba; Aslan, Ayse Tana; Kose, Mehmet; Pekcan, Sevgi; Ezgu, Fatih Suheyl; Budakoglu, Isil Irem; Yenicesu, IdilSevere anemia is reported to occur rarely in patients with cystic fibrosis (CF). This study aimed to determine the factors associated with early severe anemia in infants with CF. This study included 231 infants with CF from 3 pediatric CF centers ten year period that were retrospectively reviewed in terms of severe anemia as the first sign of CF. Factors that could affect anemia, such as age, pancreatic insufficiency, mutations, vitamin A and E, and albumin level were evaluated. Clinical and laboratory findings in CF patients that presented with severe anemia and no respiratory symptoms were compared to those in CF patients that did not present with severe anemia. Severe anemia as the first sign of CF was noted in 17 of 231 patients. Patient age, prolonged PT/INR and the albumin level differed significantly between the 2 groups of patients (P < 0.001). Feeding pattern, pancreatic insufficiency, vitamin E and A levels, and the types of genetic mutations did not differ between the 2 groups. The mean hemoglobin level was 5.59 +/- 0.21 g/dL and respiratory symptoms began a mean 6.3 months after diagnosis of CF in the anemia group. Conclusion: In early infancy severe anemia in the absence of respiratory symptoms can be the first sign of CF. CF should be considered in the differential diagnosis of severe anemia in infants. Anemia can occur several months before respiratory symptoms in patients with CF and may be caused due to several reasons.Öğe Loneliness, Hopelessness, Anxiety and Self Compassion of Medical Students: Gazi Example(Gazi Univ, Fac Med, 2014) Budakoglu, Isil Irem; Karaoglu, Nazan; Coskun, OzlemObjective: Describing the preclinical medical students' loneliness, state and trait anxiety and hopelessness levels and comparing them with self-compassion levels were the aims of this study. Methods: On voluntary basis an anonymous questionnaire consisting of UCLA Loneliness Scale, State-Trait Anxiety Inventory, Beck Hopelessness Scale and Self Compassion Scale, as well as socio demographic questions, was administered to every one out of five preclinical-year students (n= 935) at Gazi University School of Medicine. Results: Approximately half of (54.2%) the students were female and the mean age of the sample was 19.4 +/- 1.1 years (range: 17-25 years). The 34.7 % of the sampled students were living with their family. Loneliness, trait anxiety and the hopelessness levels of the students who were not satisfied with their career selection were significantly higher than chance (p< 0.05). While loneliness, state and trait anxiety and hopelessness scores were in a positive correlation with each other, self compassion was in a negative correlation with state anxiety. Conclusion: Self compassion can be described as coping with the stressors at various stages of life. Therefore, medical profession should begin with fostering self-compassion before the compassion toward others.Öğe Loneliness, Hopelessness, Anxiety and Self Compassion of Medical Students: Gazi Example(Gazi Univ, Fac Med, 2014) Budakoglu, Isil Irem; Karaoglu, Nazan; Coskun, OzlemObjective: Describing the preclinical medical students' loneliness, state and trait anxiety and hopelessness levels and comparing them with self-compassion levels were the aims of this study. Methods: On voluntary basis an anonymous questionnaire consisting of UCLA Loneliness Scale, State-Trait Anxiety Inventory, Beck Hopelessness Scale and Self Compassion Scale, as well as socio demographic questions, was administered to every one out of five preclinical-year students (n= 935) at Gazi University School of Medicine. Results: Approximately half of (54.2%) the students were female and the mean age of the sample was 19.4 +/- 1.1 years (range: 17-25 years). The 34.7 % of the sampled students were living with their family. Loneliness, trait anxiety and the hopelessness levels of the students who were not satisfied with their career selection were significantly higher than chance (p< 0.05). While loneliness, state and trait anxiety and hopelessness scores were in a positive correlation with each other, self compassion was in a negative correlation with state anxiety. Conclusion: Self compassion can be described as coping with the stressors at various stages of life. Therefore, medical profession should begin with fostering self-compassion before the compassion toward others.Öğe Ten-year follow-up of children with hydatid cysts(Turkish Pediatrics Assoc, 2019) Eyuboglu, Tugba Sismanlar; Gursoy, Tugba Ramasli; Aslan, Ayse Tana; Pekcan, Sevgi; Budakoglu, Isil IremAim: Hydatid cystic disease is an endemic parasitic disease that is common in the world. We aimed to review the demographic, clinical and laboratory findings, and treatments and outcomes of children with hydatid cyst disease, and to determine the factors affecting treatment response in two pediatric pulmonology centers in the central region of Turkey. Material and Methods: The clinical records of patients aged below 18 years who were followed up between January 2006 and December 2016 because of hydatid cyst disease were reviewed retrospectively. The patients' ages at the time of diagnosis, sexes, living areas (rural / urban), dog contact history, presence of hydatid cyst in other family members, symptoms, organs involved, dimensions of cysts, laboratory results, treatments and post treatment responses, follow-up, and outcomes were noted. Results: In a period of 10 years, 50 pediatric patients were followed up with a diagnosis of hydatid cyst. The mean age was 9.3 +/- 0.5 years and 33 (66%) of the patients were male. Fifteen patients were living in a rural area and 35 were living in an urban area. Fifteen patients had a history of contact with a dog and 10% had a positive family history. Thirty-six patients had lung involvement, 25 had liver involvement, 14 (28%) had both lung and liver involvement, and six patients had organ involvement other than lung and liver. The indirect hemagglutination test for hydatid cyst was positive in 24 of 40 patients and Echinococcus granulosus-specific IgE positivity was detected in 8 of 17 patients. Surgery was performed in 31 patients with lung involvement and PAIR was performed in 13 patients who had liver involvement. Cyst excision was performed in two patients who had isolated spinal involvement. All patients were treated with albendazole, and additional praziquantel treatment was given to seven patients. Relapse occurred in seven patients in this period. The relapse frequency was higher in patients who had organ involvement other than in the lung and liver (p<0.05), and these patients' treatment durations were longer compared with the others (p<0.05). Conclusion: Hydatid cysts can involve different organs in children. Patients with organ involvement other than the lung and liver should be followed up carefully in terms of recurrence.Öğe Ten-year follow-up of children with hydatid cysts(Turkish Pediatrics Assoc, 2019) Eyuboglu, Tugba Sismanlar; Gursoy, Tugba Ramasli; Aslan, Ayse Tana; Pekcan, Sevgi; Budakoglu, Isil IremAim: Hydatid cystic disease is an endemic parasitic disease that is common in the world. We aimed to review the demographic, clinical and laboratory findings, and treatments and outcomes of children with hydatid cyst disease, and to determine the factors affecting treatment response in two pediatric pulmonology centers in the central region of Turkey. Material and Methods: The clinical records of patients aged below 18 years who were followed up between January 2006 and December 2016 because of hydatid cyst disease were reviewed retrospectively. The patients' ages at the time of diagnosis, sexes, living areas (rural / urban), dog contact history, presence of hydatid cyst in other family members, symptoms, organs involved, dimensions of cysts, laboratory results, treatments and post treatment responses, follow-up, and outcomes were noted. Results: In a period of 10 years, 50 pediatric patients were followed up with a diagnosis of hydatid cyst. The mean age was 9.3 +/- 0.5 years and 33 (66%) of the patients were male. Fifteen patients were living in a rural area and 35 were living in an urban area. Fifteen patients had a history of contact with a dog and 10% had a positive family history. Thirty-six patients had lung involvement, 25 had liver involvement, 14 (28%) had both lung and liver involvement, and six patients had organ involvement other than lung and liver. The indirect hemagglutination test for hydatid cyst was positive in 24 of 40 patients and Echinococcus granulosus-specific IgE positivity was detected in 8 of 17 patients. Surgery was performed in 31 patients with lung involvement and PAIR was performed in 13 patients who had liver involvement. Cyst excision was performed in two patients who had isolated spinal involvement. All patients were treated with albendazole, and additional praziquantel treatment was given to seven patients. Relapse occurred in seven patients in this period. The relapse frequency was higher in patients who had organ involvement other than in the lung and liver (p<0.05), and these patients' treatment durations were longer compared with the others (p<0.05). Conclusion: Hydatid cysts can involve different organs in children. Patients with organ involvement other than the lung and liver should be followed up carefully in terms of recurrence.