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    Associations between Emotional Eating and Metabolic Risk Factors at Adolescents with Obesity
    (Lifescience Global, 2020) Sayin, Fatma Kubra; Buyukinan, Muammer; Deniz, Cigdem Damla; Arslan, Derya
    Purpose: This study aimed to determine whether emotional eating (EE) and uncontrolled eating (UCE) scores affect the metabolic risk factors in obese adolescents. Methods: A sample of 100 adolescents have BMI-SDS between 1.41 and 2.83 (aged 12-17 years) was selected. EE and UCE scores were estimated using the TFEQ21. The association of EE and UCE with anthropometric data, lipid profile, glucose profile, liver enzymes, and inflammation factors was assessed in boys and girls. Results: Using Spearman rank correlation, EE scores significantly correlated with uric acid (r = 0.393 and P = 0.001), CRP (r = 0.273 and P = 0.017), TG (r = 0.317 and P = 0.001), TC (r = 0.258 and P = 0.019) and VAI (r = 0.276 and P = 0.034). Also UCE scores were showed positive correlation with CRP (r = 0.257 and P = 0.024). Conclusion: In conclusion, interrelationships tend to exist between EE and triglyceride, uric acid, visceral adiposity index, and CRP levels among obese adolescents.
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    Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
    (Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
    Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
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    Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
    (Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
    Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
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    Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome
    (Cambridge Univ Press, 2019) Aslan, Eyup; Sert, Ahmet; Buyukinan, Muammer; Pirgon, Mustafa Ozgur; Kurku, Huseyin; Yilmaz, Hakan; Odabas, Dursun
    Purpose: The aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels. Methods: A total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness. Results: Obese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure. Conclusions: The results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.
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    PLASMA miR-103 AND miR-107 LEVELS IN OBESE CHILDREN: THE SIGN OF INSULIN RESISTANCE
    (Nobel Ilac, 2020) Tuzlukaya, Tuba; Yerlikaya, Fatma Humeyra; Can, Ummu Gulsum; Buyukinan, Muammer
    Objective: In this study, it is aimed to research how plasma miR-103 and miR-107 levels are related to insulin resistance changed when comparing obese children to healthy normal-weight children. Material and Method: The study was made on 40 obese children aged 5-17 and with 40 healthy normal-weight children aged 5-17. Plasma miR-103 and miR107 expressions were analyzed using the Real Time-PCR method. Results: miR-103 and miR-107 values about an obese group were significantly found higher (p<0.001) than a control group. It was found a statistically significant level of positive correlation in obese children between miR-103 and body mass index (BMI) (p<0.001) and BMI-p (p<0.01), insulin (p<0.01) and HOMA-IR (p<0.01). Also, it was found the statistically significant level of positive correlation in obese children between miR-107 and BMI (p<0.01), and insulin (p<0.05) ve HOMA-IR (p<0.05). Conclusion: In the light of our findings, we can say that obesity increases plasma miR-103 and miR-107 levels in children and these microRNAs showed a positive correlation with parameter HOMA-IR used to evaluate insulin resistance and insulin. miR-103 and miR-107 can shed impressive progress for understanding glucose homeostasis, whether in normal physiology or human disease.
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    Serum levels of soluble urokinase plasminogen activator receptor as a new inflammatory marker in adolescent obesity
    (Wolters Kluwer Medknow Publications, 2017) Can, Ummugulsum; Buyukinan, Muammer; Yerlikaya, Fatma Humeyra
    Background & objectives: Obesity is known for low-grade inflammatory state with enhanced production of inflammatory mediators in children and adolescents. Soluble urokinase plasminogen activator receptor (suPAR) can be generated as a pro-inflammatory marker. This study was conducted to evaluate the role of suPAR, and its association with leptin, adiponectin, interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP) and fibrinogen in adolescent obesity. Methods: A total of 98 participants, 55 obese individuals and 43 healthy controls, aged between 10 and 17 yr, were included in the study. Serum suPAR, IL-6, leptin and adiponectin were measured using ELISA method. Results: Serum suPAR, IL-6, fibrinogen, hsCRP and leptin levels in obese individuals were significantly higher than those of controls (P < 0.05 & P < 0.001). Serum adiponectin levels in obese individuals were significantly lower than those of controls (P < 0.01). Interpretation & conclusions: Our findings showed that suPAR, IL-6, fibrinogen, hsCRP and leptin were significantly higher in the obese individuals than those of controls. suPAR may be a good novel biomarker for systemic subclinical inflammation and immune activation linked to adolescent obesity.
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    Sleep Duration and Media Time Have a Major Impact on Insulin Resistance and Metabolic Risk Factors in Obese Children and Adolescents
    (Mary Ann Liebert, Inc, 2016) Sayin, Fatma Kubra; Buyukinan, Muammer
    Background: Lifestyle factors sleep duration and media time during childhood differ between countries. This study examined whether sleep duration and media time affect metabolic risk factors insulin resistance (IR), blood lipid profile, and liver enzymes, and whether there is a relationship between sleep time and media time in Turkish obese children and adolescents. Methods: Subjects included 108 obese children and adolescents (aged 10-15 years) whose lifestyle factors were assessed using a survey containing questions about sleep durations, television viewing, media use, and demographic factors. Metabolic risk factors were compared among groups categorized according to sleep and media duration. Results: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and triglyceride (TG) levels and homeostasis model assessment of insulin resistance (HOMA-IR) values were higher in subjects who spent >5 hours/day on media. Children 10-13 years old who slept <9 hours/day were more likely to have higher insulin and HOMA-IR (p<0.05) levels and lower high-density lipoprotein cholesterol (HDL-C) levels compared with subjects who slept 9-10 hours/day and >10 hours/day. Correlation analysis revealed a negative relationship between sleep time and media time (r=-0.471, p=0.000). Conclusions: Short sleep duration was associated with IR and an elevated plasma lipoprotein profile in children and adolescents. Our results suggest that insufficient sleep and excessive media exposure may contribute to metabolic risk in the context of obesity, and therefore, working to improve sleep duration and limit media time could help reduce metabolic risk in obese children and adolescents.