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    Beta-Hydroxy-Beta-Methyl-Butyrate, L-glutamine, and L-arginine Supplementation Improves Radiation-Induce Acute Intestinal Toxicity
    (Taylor & Francis Ltd, 2019) Yavas, Cagdas; Yavas, Guler; Celik, Esin; Buyukyoruk, Ahmet; Buyukyoruk, Cennet; Yuce, Deniz; Ata, Ozlem
    We aimed to evaluate effects of beta-hydroxy-beta-methylbutyrate, L-glutamine, and L-arginine (HMB/GLN/ARG) on radiation-induced acute intestinal toxicity. Forty rats were divided into four groups: group (G) 1 was defined as control group, and G2 was radiation therapy (RT) control group. G3 and G4 were HMB/GLN/ARG control and RT plus HMB/GLN/ARG groups, respectively. HMB/GLN/ARG started from day of RT and continued until the animals were sacrificed 10 days after RT. The extent of surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, crypt distortion, regenerative atypia, vascular dilatation and congestion, and fibrosis were quantified on histological sections of intestinal mucosa. Statistical analyses were performed using the analysis of variance (ANOVA) test. There were significant differences between study groups regarding extent of surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis and crypt distortion, regenerative atypia, vascular dilatation and congestion, and fibrosis (p values were 0.019 for fibrosis, <.001 for the others). Pair-wise comparisons revealed significant differences regarding surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, vascular dilatation, and congestion between G2 and G4 (p values were <.001, .033, <.001, .007, and <.001, respectively). Fibrosis score was significantly different only between G1 and G2 (p = .015). Immunohistochemical TGF-beta score of G2 was significantly higher than G1 and G3 (p values were .006 and .017, respectively). There was no difference between TGF-beta staining scores of G2 and G4. Concomitant use of HMB/GLN/ARG appears to ameliorate radiation-induced acute intestinal toxicity; however, this finding should be clarified with further studies.
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    Effects of migraine on anxiety, depression symptoms and quality of life: A hospital-based study
    (Bayrakol Medical Publisher, 2022) Buyukyoruk, Cennet; Kutlu, Ruhusen; Genc, Emine
    Aim: Migraine has a great detrimental effect on the daily life of the patient by making negative effects on socioeconomic functioning and quality of life. In this study, it was aimed to evaluate the symptoms of anxiety, depression and quality of life in patients with and without migraine and to determine the factors affecting them. Material and Methods: This analytical typed case-control study was conducted on 402 people over the age of 18. 201 of whom had migraine and 201 did not have migraine. Hospital Anxiety and Depression Scale (HADS) and World Health Organization Quality of Life Scale Short Form (WHOQOL-BREF TR) were used to collect data about patients. Results: In the present study, 90.5% (n=182) of patients with migraine were female, 80.1% were married, 58.2% had secondary school education, 21.9% were smokers. Among the factors that triggered the migraine attack, noise ranked first with a frequency of 78.1% (n=157). Anxiety and depression scores were significantly higher in those with migraine than in those without migraine (p<0.001). Quality of life parameters such as physical health, psychological health, social relations and environmental area scores were significantly higher in those without migraine than in those with migraine (p<0.001). General health and life satisfaction of the individuals without migraine were significantly higher (p<0.001). Discussion: Migraine must be taken seriously since it has a negative impact on patients' lives. Besides medical treatment, patients should be evaluated carefully for their quality of life and psychiatric conditions. As family physicians, we must approach our patients holistically.