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Öğe Can YKL-40 be an inflammatory biomarker in vitamin D deficiency?(Wiley-Blackwell, 2016) Can, U.; Uysal, S.; Ugur, A. R.; Toker, A.; Uysaler, A.; Hidayetoglu, B. T.[Abstract Not Availabe]Öğe The investigation of circulating microRNAs associated with lipid metabolism in childhood obesity(Wiley, 2016) Can, U.; Buyukinan, M.; Yerlikaya, F. H.Background: Childhood obesity is an increasing health challenge related to increased risk of chronic diseases. microRNAs (miRNAs) are noncoding short RNA molecules regulating multiple biological processes linked to obesity. Objectives: We aimed at evaluating the association between circulating miRNA levels and lipid metabolism in obese and non-obese children and adolescents. Methods: By constituting study group, 45 obese children and adolescents were recruited. To perform comparisons with study group, 41 lean controls were matched for age and sex. Using real-time quantitative PCR analysis, circulating miRNAs were evaluated in both groups. Results: Circulating miR-335 (P < 0.001), miR-143 (P = 0.001) and miR-758 (P = 0.006) in obese children were significantly lower than those of controls. However, circulating miR-27 (P = 0.032), miR-378 (P < 0.001) and miR-370 (P = 0.045) in obese children were significantly higher, compared with those of controls. In addition, circulating miR-33 in obese children was higher than those of controls, but no significant difference was present (P = 0.687). Conclusion: Our findings showed that a significant association is present between circulating miR-370, miR-33, miR-378, miR-27, miR-335, miR-143 and miR-758 values, and childhood obesity. Low levels of miR-335, miR-143 and miR-758, and high levels of miR-27, miR-378, miR-33 and miR-370 may have been responsible for elevated triglycerides and low-density lipoprotein (LDL-C) levels, and low level of high-density lipoprotein (HDL-C) in obese subjects. Therefore, miRNAs may be a good novel biomarker for childhood obesity.Öğe The relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemia(Comenius Univ, 2019) Yerlikaya, F. H.; Can, U.; Alpaydin, M. S.; Aribas, A.OBJECTIVES: The aim of the study was to investigate the relationship between plasma microRNA expression levels, which are associated with lipid metabolism and serum trace element levels in patients with primary hyperlipidemia. METHODS: This study was performed on 46 (21M / 25F) primary hyperlipidemia patients aged 25-65 years and 37 (18 M/19 F) healthy people aged 25-65 years. RESULTS: The following miRNAs were upregulated: miR-33a-5p, miR-370-5p, miR-378a-3p, miR-27a-3p, miR-27a-5p and miR-335-5p. Additionally, the levels of Co (p < 0.001), Ni (p < 0.01), Cd (p < 0.001) were significantly higher and the level of Cr (p < 0.01), Fe (p < 0.05), Mn (p < 0.01), Se (p < 0.001) and Mo (p < 0.001) was significantly lower in the primary hyperlipidemic patients compared to the healthy people. Also, miR-33a-5p was negatively correlated with serum Cr levels in patients with primary hyperlipidemia (r = -0.376, p < 0.05). CONCLUSIONS: Our study demonstrates that miR-33a-5p and Cr element may regulate abnormal lipid homeostasis. Also, miR-370, miR-378, miR-27-a and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemiaÖğe The role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease(Wiley-Blackwell, 2014) Can, U.; Yerlikaya, F. H.; Yosunkaya, S.[Abstract Not Availabe]
