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    Effectiveness of Mesenchymal Stem Cell Therapy for COVID-19 Patients in the Intensive Care Unit: A Case-Control Study
    (Galenos Publ House, 2022) Canbaz, Hayri; Idiz, Ufuk Ofuz; Dal, Hayriye Cankar; Kaciroglu, Fatih; Tas, Seher; Cubukcu, Hikmet Can; Bestemir, Attila
    Objective: Many methods are used in the treatment of coronavirus disease 2019 (COVID-19), which causes acute respiratory distress syndrome (ARDS), and there are conflicting reports in the literature regarding the results of mesenchymal stem cell (MSC) therapy, which is one of those methods. The aim of our study is to evaluate the effect of MSC treatment applied together with standard treatments on survival. Materials and Methods: This retrospective case-control study evaluates the survival effect of MSC treatment administered to patients treated in intensive care after the development of ARDS due to COVID-19 between March 2020 and March 2021. The age, gender, comorbid disease status, APACHE II score, and overall and comorbidity-based survival rates were compared between patients who received standard medical treatment (SMT) and patients who received MSC treatment together with SMT. Results: There were 62 patients in the group receiving only SMT and 81 patients in the group receiving SMT and MSC. No difference was observed between the groups in terms of age, gender, presence of comorbid diseases, or APACHE II scores. There were also no differences according to Kaplan-Maier analysis for the survival statuses of the groups. There was no serious adverse effect due to MSC treatment among these patients. Conclusion: Our study presents the largest case series in the literature, and it was observed that MSC treatment may not significantly affect overall survival or comorbid disease-based survival, in contrast to many other studies in the literature.
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    Metacognitive Beliefs and Coping Strategies of Suicide Attempters
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Yazihan, Naksidil Torun; Cinar, Orhan; Canbaz, Hayri; Ak, Mehmet
    Objective: Metacognition is an essential process regarding decision-making and coping with stressful life events. In this present study, we aimed to examine the metacognitive beliefs and coping strategies of suicide attempters with subthreshold depressive symptoms. Methods: Thirty suicide attempters (mean age of 25.50 +/- 7.66 years) with subthreshold depressive symptoms and 30 healthy participants (mean age of 28.27 +/- 7.13 years) were compared with regard to Metacognition Questionnaire-30 (MCQ-30) and COPE Questionnaire. Results: The MANOVA results revealed significant differences between the groups for the subscales of MCQ-30 namely, negative beliefs about thoughts, need to control thoughts and lack of cognitive confidence. The results also indicated significant difference regarding positive reinterpretation, seeking social support for instrumental reasons, active coping, planning, and problem-focused coping, behavioral disengagement, alcohol-drug disengagement and dysfunctional coping subscales of COPE Questionnaire. In addition, moderate correlations were found between the MCQ-30 and the COPE subscales based on the Pearson's correlation coefficients. Conclusions: This study revealed the effect of particular metacognitive beliefs and type of coping style on suicidal behavior. This study is important for identifying risk factors and explaining how metacognitive beliefs and coping strategies are related to suicidal behavior. Maladaptive metacognitions may lead to overestimation of perceived stress and underestimation of cognitive resources and coping skills which may prevent individulas to produce adaptive coping strategies against stressful life events.